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  5. TGF-β1 Modulates Formation and Function of Tight Junction and Expression of Cadherins in Cultured Ov

TGF-β1 Modulates Formation and Function of Tight Junction and Expression of Cadherins in Cultured Ov

来源 :BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中 | 被引量 : 0次 | 上传用户：cg84989679
【摘 要】
：
Ovarian surface epithelium (OSE) is the origin of epithelial ovarian tumours.During the transformation to tumour, OSE loses its mesenchymal and acquires epithelial characteristics.This transformation
【作 者】
：
Yihong Zhu 
【机 构】
：
The Department of Obstetrics and Gynecology Sahlgrenska Hospital at Gothenburg University Gothenburg
【出 处】
：
BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中
【发表日期】
：
2008年12期
【关键词】
：
TGF-β1 tight junction cadherin ovarian surface epithelium epithelial ovarian can 
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论文部分内容阅读
　　Ovarian surface epithelium (OSE) is the origin of epithelial ovarian tumours.During the transformation to tumour, OSE loses its mesenchymal and acquires epithelial characteristics.This transformation involves in de novo or increased expression of both tight junction (T J) and adherens junction (A J) proteins i.e.E-cadherin, claudin-3 and claudin-4 during ovarian tumour progression.One growth factor involved in the regulation of TJ formation in both normal and transformed epithelial cells is the transforming growth factor-β1 (TGF-β1).
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