【摘 要】
：
The multifunctional mammalian protein YB-1 is a member of the large DNA-and RNA-binding protein family with an evolutionarily ancient cold-shock domain.It is involved in numerous DNA-and mRNA-dependen
【机 构】
：
Laboratory of Tumor Cell Genetics Russian Cancer Research Center Russia
【出 处】
：
BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中
论文部分内容阅读
The multifunctional mammalian protein YB-1 is a member of the large DNA-and RNA-binding protein family with an evolutionarily ancient cold-shock domain.It is involved in numerous DNA-and mRNA-dependent events and regulates gene expression at various levels.In the cell nucleus, YB-1 functions as transcription factor interacting with Y-box m promoters and enchancers of a number of genes.In particular, YB-1 was shown to regulate the activity of the multidrug resistance (MDR) genes MDR1 and LRP.Our previous results showed that tumor cells characterized by MDR demonstrated increased number of the cells with nuclear localization of YB-1.
其他文献
Short palate, lung and nasal epithelium clone 1 (SPLUNC1) gene coded a secreted protein found at the surface of nasopharyngeal epithelium, which may be an important risk factor for nasopharyngeal carc
Background: Normal cell division is coordinated by a bipolar mitotic spindle, ensuring symmetrical segregation of chromosomes.Cancer cells may occasionally divide into three or more directions, known
The objective of this study was to evaluate the cardiac toxicity of the carboplatin, a second generation platinumcontaining anti-cancer drug, and to test the hypothesis whether low dosage ofpravastati
Anoikis resistance associates with an elevated Src activity and contributes to the cancer progression.FAK (Focal Adhesion Kinase) is a major substrate of Src and plays an important role in anoikis.To
As we age, our ability to cope with a variety of stresses significantly decreases.One of the features of an ageing organism is the dramatic increase in the number of cells arrested in the G 1 phase, a
Aberrant arachidonic acid metabolism has been suggested to play an important role in cancer progression.KMUP-1A (7-{2-[4-(2-chloropheny)piperazinyl]ethyl }-1,3-dimethyl-8-chloro-xanthine) is a newly s
In an effort to develop a test able to accurately detect early stage ovarian cancer (OC), a collaborative biomarker discovery and evaluation program has been established by a number of research instit
Proliferation and migration of lung epithelia cells are key events in developing airway inflammatory obstruction and invasive epithelial cancer metastasis.This study is designed to investigate KMUP-1
In 1969 we performed cross-immunization of children in acute phase of ALL with live leukemic cells (S.Skurkovich, et al.Nature.1969; 223:509-511) with some success.54 children with ALL, who have achie
Glioblastoma multiforme (GBM) are among the most aggressive of all known human tumors and the median survival time after GBM diagnosis remains in the 12-15 months range.The main pathologic characteris