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Aim: Total flavones of rhododendra (TFR) is a powerful antioxidant which is isolated from the traditional Chinese herb rhododendra.However, little is known regarding TFRs protective mechanism in ischemia/reperfusion (I/R) injury.TFR may have a beneficial role for neurons in cerebral ischemia/reperfusion caused by accident.We therefore observed the protective effects of TFR on neurons injured by ischemia/reperfusion in vitro and in vivo and explored the underlying mechanisms.