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  5. Propofol inhibits currents of both human ether-a-go-go-related gene and its nonsense mutation, Q738X

Propofol inhibits currents of both human ether-a-go-go-related gene and its nonsense mutation, Q738X

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：lynnxiao
【摘 要】
：
Aim: QT interval prolongation can result from intake of drugs known to affect the rapidly activating delayed rectifier K+ channel (IKr) encoded by human ethera-go-go-related gene (hERG).We aimed to in
【作 者】
：
Sheng-na HAN Li-rong ZHANG 
【机 构】
：
Department of Pharmacology,School of Medicine,Zhengzhou University,Zhengzhou,China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
propofol QT interval hERG gene Q738X mutation hERG protein trafficking 
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Aim: QT interval prolongation can result from intake of drugs known to affect the rapidly activating delayed rectifier K+ channel (IKr) encoded by human ethera-go-go-related gene (hERG).We aimed to investigate the pathophysiological consequences of a non-sense mutation, Q738X, in hERG and the effects of propofol on reconstituted wild type (WT) and Q738X hERG currents.
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