【摘 要】
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Tumor angiogenesis is critically important for the growth of solid tumors as tumors need blood vessel to support the removal of wastes from and supply of nutrients to tumor cells.Tumor angiogenesis is
【机 构】
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Department of Clinical Pharmacy,College of Pharmacy,Nanjing University of Chinese Medicine,Nanjing,2
【出 处】
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全国中药药理学会联合会学术交流大会
论文部分内容阅读
Tumor angiogenesis is critically important for the growth of solid tumors as tumors need blood vessel to support the removal of wastes from and supply of nutrients to tumor cells.Tumor angiogenesis is a complex process and involves the tight interplay of tumor cells,endothelial cells, phagocytes and their secreted factors, which may act as promoters or inhibitors of angiogenesis.Many signaling pathways involved in these processes such as VEGF, FGF, Wnt signaling pathway.However, of all the signaling pathways that involved in tumor angiogenesis,Notch signaling is a most notable one.The Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism, affecting many differentiation processes and cell-fate determination during embryonic and postnatal development.It was previously recognized that the Notch signaling plays a key role only in physiological angiogenesis such as development, wound healing and pregnancy.
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