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Objective To study the regulating mechanisms of benzene metabolites 1,4-Benzoquinone(1,4-BQ)-induced the methylation expression downregulation of stat3 gene.Methods AHH-1 cells were treated by 1,4-BQ for 24 hours with or without pretreatment of the antioxidant alpha-LA or the methyltransferase inhibitor,5-aza.