Restenosis and late thrombosis are still problems for coronary artery stent therapy. Inducing endothelialization is considered to be an effective method to solve late thrombosis and restenosis. To improve the inducing endothelialization ability of stents materials surface, this research focuses on a new technique of hyaluronic acid-dopamine (HA-PDA) hydrogel packing functional Hep/PLL nanoparticle.Several bio-functional HA-PAD hydrogel made of dopamine and hyaluronic acid in different atios were fabricated. The same amount nanoparticles were then added to HA-PDA hydrogel for obtaining the functional unfolding. The hydrogel systems were fixed onto Ti surface. The SEM results displayed that, there were much regular holes on the surface of HA-PDA hydrogel. Nanoparticles had gathered in the hydrogel. With the increase of nanoparticles concentration, the gather were more serious.Fluorescence staining results showed that the endothelial cells on HA-PAD hydrogel surface were not unfolding. The CCK-8 results of endothelial cells revealed that, the HA-PAD hydrogel at ratios of 50w-3(10mg/ml hyaluronic acid and 3mg/ml dopamine) had good cell compatibility. Finally, we performed a dyn mic evaluation of endothelial progenitor cells (EPCs) by a driving chamber to investigate the EPCs inducing ability of the loading VEGF hydrogel systems. The results disclosed that the EPCs were induced moving to the functional hydrogel surface. We hope that this method can provide more helpful exploration and application for promoting endothelialization on cardiovascular stents.