Smart pH-sensitive polymeric nanocarriers for combination chemotherapy

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户:wuusir
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  pH-sensitive polymeric nanocarriers look like the most promising tool for cancer therapy[1,2].In this work,novel pH-sensitive amphiphilic copolymers were firstly synthesized to facricate smart pH-sensitive nanocarriers for combination chemotherapy (Fig.1).
其他文献
Lysosomes are membranous acidic vesicles,which contain numerous enzymes and proteins exhibiting a variety of activities and functions at acidic pH (4.5-5.5).Thus,development of suitable fluorescent pr
Cisplatin is one of the most widely used anticancer agents[1].However,its therapeutic concentration is usually associated with dose-limiting side effects such as neurotoxicity,gastrointestinal disturb
Reconstituted high density lipoprotein (rHDL) displays dual functions in plaque targeting and anti-atherosclerosis.In our previous studies,cardiovascular drug tanshinone ⅡA (TA)-loaded rHDLs were prov
Implantable biomaterials can be applied to tissue engineering and drug delivery for sustained release of therapeutic molecules.However,the clinical implantation of biomaterials needs skilled physician
Human colon cancer is one of the major causes of cancer death worldwide.The traditional therapy mainly focuses on surgical resection combined with chemotherapy.However,chemotherapy is often accompanie
The complexity and heterogeneity of tumors have been increasingly concerned,which result in the undesirable antitumor efficacies of conventional chemotherapeutic drugs[1].Given the above background,th
Only around 100 kind of natural polymers can be directly electrospun into nanofibers,and of these only around 10 are suitable for use as pharmaceutical excipients.The ability of processing un-spinnabl
The convenience and flexibility in different chronic treatment regimes made the micellar vehicle a potential candidate for drug loading and injection treatment.Herein,two amphiphilic copolymers with s
Doxorubicin (DOX) is a widely used chemotherapeutic drug for the treatment of several types of cancers.However,its side effects and the development of multidrug resistance (MDR) greatly reduced the an
Over the last years,huge efforts have been undertaken to develop feasible polymer-based systems for biomedical applications.Hollow capsules (e.g.polymersomes) among others have been proven to be promi