A method for synthesis of the important intermediates of Olmesartan

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：bigwbiso

【摘要】

：

Objective To synthesize the important intermediates of Olmesartan.Methods 2-propyl-1H-imidazole-4,5-dicarboxylic acid diethyl ester was synthesized using tartaric acid,an easily available,inexpensive

【作者】

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WEN Xinmin

【机构】

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Department of Medicinal Chemistry,Jining Medical University,Rizhao,Xueyuan Road 669,276826

【出处】

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2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

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2015年3期

【关键词】

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2-propyl-1H-imidazole-4 5-dicarboxylic acid diethyl ester intermediates of Olmes

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　　Objective To synthesize the important intermediates of Olmesartan.Methods 2-propyl-1H-imidazole-4,5-dicarboxylic acid diethyl ester was synthesized using tartaric acid,an easily available,inexpensive and renewable substrate,as starting material via nitration,cyclization,esterifcation Results The technics was improved and toxic material was replaced.

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A method for synthesis of the important intermediates of Olmesartan

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