2. 您的位置
3. 首页
4. 会议论文
5. Molecular Modeling Studies of G-Protein-Coupled Receptor 30

Molecular Modeling Studies of G-Protein-Coupled Receptor 30

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：hyz3059611

【摘 要】

：

Breast cancer(BC)is a molecularly heterogeneous disease still remaining a leading cause of women death in many countries.Reportedly,approximately 50% of breast cancer patients express GPR30,which is c

【作 者】

：

Zunyuan WANG Wenhai HUANG Meihao LIANG Chixiao ZHANG Zhen MA Zhengrong SHEN 

【机 构】

：

Zhejiang Academy of Medical Sciences,Hangzhou,Zhejiang,310013

【出 处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

G-protein-coupled receptor (GPCR) GPR30 homology modeling breast cancer 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Breast cancer(BC)is a molecularly heterogeneous disease still remaining a leading cause of women death in many countries.Reportedly,approximately 50% of breast cancer patients express GPR30,which is consistent with development of tamoxifen resistance.

其他文献

Application of Computational Systems Toxicology in Understanding of Drug-induced Hepatotoxicity Mech

Drug-induced hepatotoxicity is a leading cause of acute liver failure worldwide and one of the most frequent reasons for the withdrawal of approved drugs from the market.[1-2] Thus,drug-induced hepato

会议

Drug-induced hepatotoxicitySystems toxicologyNetwork-based methodMolecular me

通过硝酮烯烃环加成反应合成苯并二氮芳辛衍生物

研究构建新杂环化合物的新方法一直是有机化学和药物化学中的热点课题。苯并八元环化合物是一类重要的杂环化合物，多种天然产物和活性分子中含有其结构单元[1]。硝酮烯烃环加成反应是合成异噁唑烷衍生物的重要途径，被广泛应用于天然产物和活性化合物的合成中[2]。

会议

硝酮烯烃环加成苯环体系苯并二氮芳辛内外式选择性氨基醇

In Silico Prediction of Binding Modes between Glucagon-Like Peptide-1 Receptor and Its Endogenous Ag

Diabetes,as a chronic metabolic disorder,has become the third major disease threatening the health of human being,and type 2 diabetes mellitus(T2DM)accounts for 90%of cases diabetes.Diabetes patients

会议

GLP-1Rhomology modelingmolecular dynamics simulationMM-PBSA

Discovery of Fused and Spiro Compounds as Inhibitors of SETD8

SETD8/SET8/Pr-SET7/KMT5A is the sole protein lysine methyltransferase(PKMT)that catalyzes the monomethylation of histone H4 lysine 20(H4K20).[1] Because of the diverse biological functions of SETD8,th

会议

SETD8methyltransferaseinhibitorFused and Spiro Compounds

Identification of Small-Molecule Activators of Staphylococcus aureus ClpP Protease

The number of bacterial strains resistant to antimicrobial agents is continuously increasing,thus warranting the rapid development of new drugs with novel mechanisms of killing bacterial cells1.

会议

ClpP proteaseADEPsvirtual screeningantibacterial treatment

Discovery of Novel Selective ER Subtype Ligands

Estrogen receptor is involving in hormone-regulated cancer and Alzheimer.There are two subtypes of ER,ERα and ERβ,the function of which are up-or down-regulating the related gene expression in target

会议

Selective ERα/ERβ ligandsPharmacophore modelVirtual screening

Synthesis,Structural Characterization and Antibacterial Activities of N-Substituted Benzylidene Arom

Series of N-substituted benzylidene aromatic amine were synthesized.Their structures were characterized by NMR spectrum.Some crystal structures were refined through the SHELXL97 software processing.

会议

SynthesisStructural characterizationBenzylidene aromatic amine

Synthesis,Structural Characterization and Antibacterial Activities of Series of(Z)-4-oxo-4-(arylamin

Series of(Z)-4-oxo-4-(arylamino)but-2-enoic acid derivatives were synthesized.Their structures were characterized by NMR spectrum.

会议

SynthesisStructural characterization(Z)-4-oxo-4-(arylamino)but-2-enoic Acid

Synthesis,Structural Characterization and Antibacterial Activities of Series of Chalcone Derivatives

Series of chalcone derivatives were synthesized.Their structures were characterized by NMR spectrum.The results showed that trans-structure were the main products,which exhibited the C=C double bond w

会议

SynthesisStructural characterizationChalcone

Design and synthesis of novel pyrimidine-amide conjugates

Pyrimidines play an important role in the drug discovery process,and have considerable pharmacological and chemical significance.[1] Pyrimidines have been recognized as important heterocyclic compound

会议

pyrimidineamidesynthesispharmacologicalanticancer