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目的:净化受微生物感染的基因修饰小鼠.方法:通过获取基因修饰小鼠的2-细胞期胚胎,将胚胎充分清洗并移植入假孕小鼠的输卵管中.结果:产仔率为39.8％,通过对新生鼠和假孕雌鼠进行微生物检测,所有指标均符合SPF级要求.结论:采用胚胎移植技术可有效净化受感染的小鼠种群.
胚胎移植术进行基因修饰小鼠的生物净化
【摘 要】
：
目的:净化受微生物感染的基因修饰小鼠.方法:通过获取基因修饰小鼠的2-细胞期胚胎,将胚胎充分清洗并移植入假孕小鼠的输卵管中.结果:产仔率为39.8％,通过对新生鼠和假孕雌鼠进行微生物检测,所有指标均符合SPF级要求.结论:采用胚胎移植技术可有效净化受感染的小鼠种群.
【机 构】
：
华中科技大学同济医学院实验动物学部,430030
【出 处】
：
第十七届中南地区实验动物科技交流会
【发表日期】
：
2017年6期
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