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  5. His-tag-based Silica Nanoparticles for Oral Delivery and Controllable Release of Peptide and Protein

His-tag-based Silica Nanoparticles for Oral Delivery and Controllable Release of Peptide and Protein

来源 :The 6th International Conference on Nanoscience and Technolo | 被引量 : 0次 | 上传用户：buctdai
【摘 要】
：
The oral administration is the most preferred drug delivery method for its convenience and high degree of patient acceptability and compliance.But oral administration of peptide and protein drugs is s
【作 者】
：
Zhuxue Shao Xiaowei Yang Sheng-Tao Yang Haifang Wang Yuanfang Liu Aoneng Cao 
【机 构】
：
Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai 200444, China
【出 处】
：
The 6th International Conference on Nanoscience and Technolo
【发表日期】
：
2015年5期
【关键词】
：
Protein drug delivery oral administration controlled release His-tag Silica Nano 
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　　The oral administration is the most preferred drug delivery method for its convenience and high degree of patient acceptability and compliance.But oral administration of peptide and protein drugs is still impractical,due to their poor intrinsic permeability,enzymatic degradation,rapid clearance,and chemical and conformational instability.
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