【摘 要】
：
Nutrient transporters have been explored for biomimetic delivery targeting the brain.The albumin-binding proteins(e.g.,SPARC and gp60)are overexpressed in many tumors for transport of albumin as an am
【机 构】
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Shangai Institute of Materia Medica,Chinese Academy of Sciences
【出 处】
：
中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
Nutrient transporters have been explored for biomimetic delivery targeting the brain.The albumin-binding proteins(e.g.,SPARC and gp60)are overexpressed in many tumors for transport of albumin as an amino acid and an energy source for fast-growing cancer cells.However,their application in brain delivery has rarely been investigated.In this work,SPARC and gp60 overexpression was found on glioma and tumor vessel endothelium; therefore,such pathways were explored for use in brain-targeting biomimetic delivery.We developed a green method for blood-brain barrier(BBB)-penetrating albumin nanoparticle synthesis,with the capacity to coencapsulate different drugs and no need for cross-linkers.The hydrophobic drugs(i.e.,paclitaxel and fenretinide)yield synergistic effects to induce albumin self-assembly,forming dual drug-loaded nanoparticles.
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