考察苏格木勒-3汤对异丙肾上腺素所致大鼠心肌肥厚的保护作用并探讨其机制.皮下注射大剂量异丙肾上腺素致大鼠心肌肥厚模型,以苏格木勒-3汤灌胃给药,观察大鼠心脏外观、心脏指数;光镜观察心脏组织形态学变化,用分光光度法及实时定量PCR检测Caspase-3/9的活性和表达情况.与正常对照组相比,异丙肾上腺素处理组心脏变大,缺血,心脏指数升高,病理损伤严重,苏格木勒-3汤改善心脏形态及心脏组织病理变化,降
OBJECTIVE: Refractory wound is a dreaded complication of diabetes and is highly correlated with endothelial precursor cell (EPC) dysfunction caused by hyperglycemia.Acarbose is a widely used oral gluc
OBJECTIVE.Coronary heart disease (CHD) has been the leading cause of death around the world for the past decades.Aspirin (ASA) has established efficacy for preventing cardiovascular events and is pres
目前,心脑血管疾病是全世界死亡率最高的疾病之一,且发病率正呈现上升趋势.传统中药用于防治心脑血管疾病积累了丰富的临床经验.丹参是著名的活血化瘀中药,其主要成分包括酚酸类和丹参酮类.丹参酮类是一类脂溶性萜醌类天然产物,其中的丹参酮ⅡA衍生物-丹参酮ⅡA磺酸钠已经广泛应用于临床.越来越多的研究显示,丹参酮类抗动脉粥样硬化、抗心律失常、抗高血压以及抗缺血再灌注等方面作用显著.本文将对丹参酮类的防治心脑血
OBJECTIVE To investigate the anit-inflammatory effect of extracts of Dendropanax dentiger (Harms) Merr and Lycopodiastrum casuarinoides (Spring) Holub on rheumatoid arthritis (RA) using adjuvant arthr
OBJECTIVE Epithelial-mesenchymal transition (EMT) is a phenotype conversion that plays a critical role in the development of pulmonary fibrosis (PF).It is known that a transcription factor snail could
OBJECTIVE Experimental autoimmune encephalomyelitis (EAE), the classical animal model for multiple sclerosis (MS) is triggered by an impaired balance of T helper (Th) cells and regulatory T (Tregs) ce
OBJECTIVE It has been supposed that mast cells have important participation in the physiopathology of RA, however, the role of mast cells in the pathogenesis of RA remains unclear.In this study, we ob
OBJECTIVE Recently, some reports show that curcuma has a good curative effect on the treatment of psoriasis; while curcuma has many components, so the present study was designed to investigate the eff
OBJECTIVE To investigate the effects of salvianolic acid A (SAA) in systemic lupus erythematosus (SLE) induced by pristane in BALB/c mice, this study was performed.