Discovery of a Novel NO-Donating Bifendate Derivative with Promising Action against both Drug-Suscep

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户：caj978879947

【摘要】

：

【作者】

：

Yihua Zhang

【机构】

：

Center of Drug Discovery,China Pharmaceutical University,Nanjing 210009

【出处】

：

第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会

【发表日期】

：

2012年8期

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　　Multidrug resistance(MDR) is a major obstacle to successful cancer chemotherapy,and novel biologically based treatment strategies that can overcome MDR are urgently needed.1,2 In this study,a series of novel nitric oxide(NO)-donating bifendate derivatives(7a-n) were synthesized and evaluated for their anticancer activities in both conventional therapy-susceptible and-resistant tumor cells.

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