RAPAMYCIN相关论文
In the present study,we introduced point mutations into Ac_rapA which encodes a polyketide synthase responsible for rapa......
Comparative analysis of rapamycin biosynthesis clusters between Actinoplanes sp.N902-109 and Strepto
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Rapamycin loaded magnetic graphene oxide nanoparticles as tumor-targeted drug delivery system:synthe
With the development of nanotechnology,many kinds of functional targeted nanoparticles have been applied for cancer trea......
Rapamycin Induces Megakaryocytic Differentiation through increasing autophagy in Human Megakaryoblas
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Purpose: Previous literatures have showed that osteocyte is the orchesyrator of the bone remolding and agerelated decrea......
Objective Currently the four means of treating cancer are surgery,radiotherapy,chemotherapy and biological therapy.Tumor......
Purpose This study aims to examine the efficacy of rapamycin on transforming growth factor(TGF)-β2-stimulated prolifera......
The mechanistic (or mammalian) target of rapamycin (mTOR) is an evolutionarily conserved protein kinase with central rol......
Background:In this study,we investigated the mechanism underlying the effects of the mTOR protein kinase inhibitor rapam......
RapamycinRegulates the Expression of Krüppel-Like Transcription Factor 2 Through nonphosphorylates a
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Extensive research has shown that the aggregation and toxicity of amyloid -beta protein (A β) are closely related to th......
Preparation and experimental research into retrievable rapamycin-and heparin-coated vena cava filter
The use of retrievable vena cava filters(RVCFs)was once commonplace,but filter retrieval was often very difficult.Most u......
CLONING AND CHARACTERIZATION OF THE PARTIAL RAPAMYCIN-BIOSYNTHETIC GENE CLUSTER FROM ACTINOPLANES SP
Rapamycin is one of triene macrolide antibiotics.It is used in clinics as a potent immunosuppressant with antifungal and......
Inhibition of HMGB1 attenuate podocyte apoptosis and epithelial-to-mesenchymal transition(EMT)throug
Background:Podocyte injury is the major causative factor of diabetic nephropathy(DN).Podocyte injury is characterized by......
Background Rapamycin is an immunosuppressant drug, and rapamycin-coated stents inhibit endothelial proliferation and pre......
Backgrounds Previous studies identified KLF2 as a key "molecular switch" that regulated the expression of TF,and eNOS.......
Rapamycin inhibits BAFF stimulated cell proliferation and survival by suppressing mTOR-mediated PP2A
B-cell activating factor (BAFF) is involved in not only physiology of normal B cells, but also pathophysiology of aggres......
Cadmium (Cd),a toxic environmental contaminant,contributes to neurodegeneration.Rapamycin,a macrocyclic lactone,has rece......
The mammalian target of rapamycin (mTOR) signaling pathway is a master regulator of cell growth.Recently,inhibition of m......
Background:Lupus nephritis(LN)is oneof the most common and severe complications in Systemic lupus erythematosuspatients,......
mTOR(mammalian target of rapamycin),a serine/threonine kinase,plays a central role in cell growth,proliferation,metaboli......
星形胶质细胞在疾病和损伤条件下对神经元的功能和完整性起着重要作用。目前已经明确星形胶质细胞上表达的谷氨酸转运体2 (GLT1)在......
Rapamycin production of mutant strain obtained by ultraviolet mutagenesis increased to 426.7 mg/L,approximately 5.8-fold......
Induction of autophagy reduces markers of renal endoplasmic reticulum stress in Glycogen Storage Dis
Glycogen Storage Disorder Type la (GSD1a), also known as von Gierkes disease, is the most common Glycogen Storage Disord......
Nuclear phosphoproteome reveals that EGF Regulates Alternative Splicing through mTORC1 pathway in MD
Aberrant epidermal growth factor receptor (EGFR) signaling is a typical characteristic of many human malignancies.Emergi......
目的 研究脊髓损伤后自噬相关蛋白Beclin1、LC3的表达变化对自噬发生的影响.方法 构建大鼠脊髓横断损伤模型,分别于损伤后0h、4h、......
目的 研究脊髓损伤后自噬相关蛋白Beclin1、LC3的表达变化对自噬发生的影响。方法 构建大鼠脊髓横断损伤模型，分别于损伤后0h、4h、......
Increased autophagic activity in dorsal root ganglion attenuates neuropathic pain following peripher
Autophagy is a process of cellular self-cannibalization, and provides an adaptive mechanism to protect cells against div......
Most of breast cancers are resistant to mammalian target of rapamycin complex I (mTORC1) inhibitors rapamycin and rapalo......
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The effects of rapamycin on the differentiation and proliferation of CD4+CD25+ regulatory T cells in
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Rapamycin induce Foxp3+ CD4+CD25+ regulatory T cells generation via promoting Transforming growth fa
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As sessile organisms,plants must adapt to variations in the environment.Environmental stress triggers various responses,......
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新型免疫抑制剂Rapamycin具有优于环孢菌素、FK506的免疫抑制活性。它能抑制生长因子或细胞因子引起的细胞增殖。动物实验表明它对......
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Effects of Rapamycin on Clinical Manifestations and Blood Lipid Parameters in Different Preeclampsia
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CD4~+Foxp3~+ regulatory T cells converted by rapamycin from peripheral CD4~+ CD25~-naive T cells dis
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Rapamycin attenuates bleomycin-induced pulmonary fibrosis in rats and the expression of metalloprote
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The proportion of liver transplantation(LT)for hepatocellular carcinoma(HCC)has kept on increasing over the past years a......
The prevalence of type 2 diabetes(T2D)continues to rise despite the amount of research dedicated to finding the culprits......
Objectives:Mechanistic target of rapamycin (mTOR) activation has been identified in keloid.This study aimed to identify ......
