PHARMACOGENOMICS相关论文
Non-small cell lung cancer is recognized as the deadliest cancer across the globe.In some areas,it is more common in wom......
RePhine: An Integrative Method for Identification of Drug Response-related Transcriptional Regulator
Transcriptional regulators (TRs) participate in essential processes in cancer pathogenesis and are critical therapeutic ......
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Computational analysis and prediction of miRNA-based pharmacogenomics on anti-cancer small molecules
In last decade,the “one drug,one gene,one disease” paradigm limited the development of new drugs,thus growing pharmaco......
Population pharmacokinetics and pharmacodynamics study of S-and R-warfarin in heart valvular replace
Aims: The purposes of this study were to establish population pharmacokinetic-pharmacodynamic (PopPK-PD) models of S-and......
Association between SLC17A7 gene polymorphisms and venlafaxine for major depressive disorder in a Ch
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Association between SLC17A7 gene polymorphisms and venlafaxine for major depressive disorder in a Ch
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The response rate of most anti-cancer drugs is limited because of the high heterogeneity of cancer and the complex mecha......
Genetic polymorphisms of pharmacogenomic very important pharmacogenes variants in Chinese Lisu popul
OBJECTIVE The specificity of drug therapy in individuals and races has promoted the development and improvement of pharm......
Objective::Venlafaxine is a common antidepressant and its therapeutic effect varies among people with different genetic ......
左乙拉西坦（LEV）是第二代广谱抗癫痫药，与其他抗癫痫药相比，具有独特的抗癫痫机制、良好的疗效及耐受性。随着LEV的广泛应用，其不良反应......
近年来,根据肿瘤个体基因特征进行个体化治疗正日益成为国内外学者关注的焦点.对结直肠癌患者进行药物基因组学研究发现,谷胱甘肽......
氢氯噻嗪是常用的高血压降压药物,疗效受到患者药物基因组学特征影响.现综述近年来的相关研究进展,蛋白激酶C-α基因的rs16960228......
药物基因组学(PGx)主要研究基因多态性等遗传特性对药物代谢、药效和药物不良反应的影响,旨在为新药研发、临床试验、注册上市、个......
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目的:分享北京朝阳医院精准用药门诊模式,总结就诊患者特点和精准用药调整手段,分析开设精准用药门诊的利弊,希望为国内未来精准用......
基于药物基因组学的个体化医疗是未来医学发展的方向,心血管疾病方面的药物基因检测在各大医院得到了迅速的推广,但由于技术成本高......
开发药物基因组相关用药指导查询软件手机APP,可以解决英文数据库阅读不方便,纸质专业书籍信息更新缓慢和查询不便捷等问题.我们归......
药物基因组学是一门从基因角度研究药物作用个体间差异的学科,对于患者个体化治疗具有重要意义。近年来,在抗肿瘤药物研究方面,药......
Conventionally, in the pharmacokinetic/pharmacodynamic analysis of small molecule compounds such as cytotoxic anticancer......
Pharmacogenomics is the study of the impact of genetic variations or genotypes of individuals on their drug response or ......
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Non-small cell lung cancer is a prevalent and rapidly-expanding challenge to mode medicine. While generalized medicine w......
,Pharmacogenomics and personalized medicine: a review focused on their application in the Chinese po
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本文通过对荣华二采区10...
The Promise of Pharmacogenomics in Reducing Toxicity During Acute Lymphoblastic Leukemia Maintenance
Pediatric acute lymphoblastic leukemia(ALL) affects a substantial number of children every year and requires a long and ......
近年来,药物基因组学(pharmacogenomics)研究收集了大量有关遗传多态性对药物反应(疗效和毒性反应)的普遍影响的信息,并突出显示了......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
FKS06是肝移植术后常用的免疫抑制剂,存在治疗窗狭窄、个体间和个体内变异性大等特点.对移植患者术后血药浓度的监测是目前临床免......
Pharmacogenetics and pharmacogenomics deal with the role of genetic factors in drug effectiveness and adverse drug react......
现代药物基因组学研究证明,人类遗传和基因多态性是药物不良反应及其疗效个体差异的首要原因.个体化医学则是根据个体的遗传结构,......
Biochip as a new research field has enjoyed its rapid development in the past 10 years. Using microfabrication technolog......
药物基因组学是研究基因组变异与药物疗效、安全性间关系的学科.本文主要介绍临床常用降糖药的药物基因组学研究进展.......
氨氯地平为第3代二氢吡啶类钙拮抗剂,是临床上常用的治疗高血压和心绞痛的药物之一,其降压效果存在个体差异.这种差异是多种遗传因......
Interindividual differences in the toxicity and response to anticancer therapies are currently observed in practically a......
青光眼是全球第二大致盲疾病，眼压增高是其主要危险因素，前列腺素类药物是新型的抗青光眼药物，广泛应用于临床，但其药物反应个体差异大......
氯吡格雷是临床应用最广泛的抗血小板药物,能有效预防或减低动脉血栓及经皮冠状动脉介入术(percutaneous coronary intervention,P......
Commonly observed aberrations in epidermal growth factor receptor(EGFR) signaling have led to the development of EGFR-ta......
In the treatment of tumor patients, how to select the chemotherapy regimen with better efifcacy, less toxicity and expen......
利尿剂是治疗高血压的一线药物。长期使用利尿剂会导致血糖升高、电解质紊乱(最常见的是低钾血症)、脂代谢异常(如甘油三脂、胆固......
目的:探索治疗抵抗精神分裂症(TRS)患者抗精神病药代谢基因细胞色素氧化酶(CYP450)多态性。方法:收集80例TRS患者(TRS组)和47例非T......
高血压病及其相关的心血管疾病已成为导致死亡的首要原因之一;但全球药物降压达标率仍较低,其原因之一与个体间药物疗效差异较大相......
药物基因组学是“精准医学”的基石，基于临床实际和高校自身改革的需求，有必要开设药物基因组学这门课程。作为一门前沿性知识内容较......
Individualized immunosuppression: new strategies from pharmacokinetics,pharmacodynamics and pharmaco
【正】The ultimate goal of transplantation is the donor-specific immune tolerance, but at least in the first 15 to 20 ye......
随着人类基因组研究的发展,药物基因组学异军突起.它可能给人们带来巨大的益处,如研究费用下降和新药开发时间的缩短等.对于医生而......
