PERK相关论文
目的 基于内质网应激（ERS）蛋白激酶R样内质网激酶（PERK）-激活转录因子4（ATF4）通路探讨小檗碱减轻高糖诱导的血管平滑肌细胞（VSMC）钙化的相......
背景和目的近年来,宫颈癌的发病率、死亡率、淋巴结受累率、远处转移率和复发率仍较高。宫颈腺癌的发病率、耐药率、复发率、卵巢......
研究背景:近年来,随着社会生活水平的提升,人口老龄化也日益加剧,对于老年疾病的研究也显得尤为重要。主动脉瓣钙化疾病（Calcific A......
研究背景:索拉非尼是第一个被批准应用于晚期肝癌治疗的分子靶向药物,它可以通过多激酶活性、多靶点信号转导阻断肝癌细胞增殖通路......
学位
目的:乳腺癌目前处于威胁女性健康的恶性肿瘤首位。多项报道表明乳腺癌中的内质网应激反应被激活。TMEM16家族与肿瘤间有着密切关......
内质网应激(Endoplasmic reticulum stress,ERS)的激活与创伤、缺血再灌注等病理刺激引起的神经元凋亡有关,流行性乙型脑炎病毒(JE......
期刊
错误/未折叠蛋白的积累可导致内质网(endoplasmic reticulum,ER)结构和功能紊乱,从而诱发内质网应激(endoplasmic reticulum stres......
目的 糖皮质激素的使用是股骨头坏死最主要的病因。研究表明，糖皮质激素可以通过诱导内皮细胞凋亡直接损伤血管，从而导致骨组织血供......
目的 探讨Mir-218在低氧性肺动脉高压中的作用及机制 方法 通过芯片筛选低氧性肺动脉高压(HPH)大鼠肺组织中差异表达的MicroRNAs,......
Dysregulation of ribosome biogenesis causes human diseases, such as Diamond-Blackfan anemia, 5q minus syndrome and bone ......
The ERK activation in the local interneurons of spinal dorsal horn is critical for histamine induced
Objective Itch has a significant negative impact on an individuals quality of life.However,the molecular mechanisms unde......
目的：观察内质网应激PERK/eIF-2a通路在非酒精性脂肪肝形成中的表达变化,探讨非酒精性脂肪肝的形成机制和运动的干预作用.方法：将8周......
The effects of Vaccaria Segetalis extract on inhibiting angiogenesis in vivo and its underlying mech
Aim: To study the effects of Vaccaria Segetalis extract (VSET) on inhibiting angiogenesis in vivo and its underlying mec......
6-Shogaol Induces Apoptosis in Human Hepatocellular Carcinoma Cells through Endoplasmic Reticulum St
6-Shogaol is an active compound isolated from Ginger (Zingiber officinale Rosc).In this work,we demonstrated that 6-shog......
Itch have a significant negative impact on an individuals quality of life.In several past years,a huge progress has been......
Inhibition of the spinal astrocytic ERK/TNF-αpathway activation correlates with the analgesic effect
Background:Neuropathic pain (NP) continues to be challenging to treat due to lack of effective drugs.Spinal astrocytes p......
The ERK activation in the local interneurons of spinal dorsal horn is critical for histamine induced
Objective Itch have a significant negative impact on an individuals quality of life.However, the molecular mechanisms un......
Melatonin relieves heat-induced spermatocyte apoptosis in mouse testes by inhibition of ATF6 and PER
Normal spermatogenic processes require the scrotal temperature to be lower than that of the body as excessive heat affec......
Ghrelin Promotes chondrogenic differentiation of Rat Mesenchymal Stem Cells through suppressing phos
Articular cartilage is an avascular connective tissue with limited capacity for self-regereration as there is no ves......
目的探究子宫内膜腺癌组织中多聚腺苷二磷酸核糖聚合酶-1(PARP-1)与Ras-MEK-ERK信号通路相关分子的表达及临床意义。方法选取2012......
目的:探讨游离脂肪酸(FFA)作用下胰岛βTC3细胞双链RNA依赖性蛋白样内质网激酶(PERK)的表达以及利拉鲁肽(Lira)对其表达的干预作用......
Melatonin relieves heat-induced spermatocyte apoptosis in mouse testes by inhibition of ATF6 and PER
Normal spermatogenic processes require the scrotal temperature to be lower than that of the body as excessive heat affec......
目的 探讨pERK和MMP-9蛋白在甲状腺乳头状癌(PTC)中的表达及其临床意义. 方法 收集168例PTC及80例癌旁正常甲状腺组织石蜡标本,采......
背景 先前研究已证明细胞自噬、凋亡及内质网应激共同参与肝细胞癌的发生、发展。索拉非尼作为晚期肝细胞癌患者的治疗用药,研究发......
目的:砷以有机和无机两种方式广泛存在于自然界中,是世界卫生组织公认的致癌物质之一。长期砷超标接触可以引发多种疾病,如神经系......
1,25-(OH)2D3 protects pancreatic beta cells against H2O2-induced apoptosis through inhibiting the PE
Endoplasmic reticulum (ER) stress plays a critical role in pancreatic β cell destruction which leads to the pathogenesi......
目的:探讨糖尿病视网膜病变患者血清PERK、CHOP和IRE水平及意义。方法:选取2016年1月—2018年8月在许昌市第五人民医院治疗的糖尿......
目的:肺纤维化(Pulmonary fibrosis,PF)是一种知之甚少,异质性的,具有显著的全球性发病率和死亡率的疾病。目前对于PF的医疗干预主......
Objective To investigate the role of activated extracellular signal-regulated kinase 1/2 (ERK1/2) in spinal cord in the ......
目的:构建人PERK基因的shRNA慢病毒载体,检测其对人牙髓细胞(dental pulp cells,DPCs)PERK基因表达的抑制作用。方法:针对人PERK基......
本实验取源于人成骨细胞肉瘤OS732细胞作为体外成骨细胞染氟模型。对其进行反转录及实时PCR和半定量PCR，并对所得数据进行统计......
,Benzyl isothiocyanate induces protective autophagy in human lung cancer cells through an endoplasmi
Isothiocyanates,such as allyl isothiocyanate (AITC),benzyl isothiocyanate (BITC),phenethyl isothiocyanate (PEITC) and su......
目的:观察PERK蛋白对结肠癌细胞药物敏感性的影响,并进一步探讨其相关作用机制.方法:结肠癌细胞系HCT116分为三组:空白对照(Contro......
内质网应激在溃疡性结肠炎发病过程中的作用已经被广泛关注。蛋白激酶R样内质网激酶(protein kinase R-like ER kinase,PERK)......
目的观察氯化镧(LaCl3)对大鼠大脑皮质星形胶质细胞(Ast)中葡糖调节蛋白-94(GRP-94)、蛋白激酶R样内质网激酶(PERK)、生长阻滞和DN......
目的观察氯化镧(lanthanum chloride,LaCl_3)对大鼠大脑皮质细胞凋亡、葡萄糖调节蛋白(glucose regulated protein,GRP)表达、PKR......
目的探讨内质网应激PERK信号通路在急性热应激诱导睾丸生殖细胞凋亡中的作用。方法将18只健康6~8周龄清洁级ICR雄性小鼠随机分为3......
目的:探讨内质网应激信号通路PERK-eIF2α参与调控口咽癌细胞增殖具体机制.方法:采用MTT实验分别检测不同浓度(0 μmmol／L、1 μmmo......
目的观察IL-6对1-甲基-4-苯基吡啶(MPP+)处理的SH-SY5Y细胞的生长和pERK的影响。方法对MPP+处理的SH-SY5Y细胞进行IL-6干预,观察细......
