ITCH相关论文
Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mi
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Antioxidants Attenuate Acute and Chronic Itch: Peripheral and Central Mechanisms of Oxidative Stress
Itch (pruritus) is one of the most disabling syndromes in patients suffering from skin,liver,or kidney diseases.Our prev......
Peripheral itch stimuli are transmitted by sensory neurons to the spinal cord dorsal horn,which then transmits the infor......
In 1905,Henry Head first suggested that transmission of pain-related protopathic information can be negatively modulated......
Nociception is an important physiological process that detects harmful signals and results in pain perception.In this re......
Pain and itch are unpleasant sensations that often accompany infections caused by viral,bacterial,parasitic,and fungal p......
The voltage-gated potassium channels involved in regulation of physiological function in MrgprA3 spe
Itch is described as an unpleasant or irritating skin sensation that elicits the desire or reflex to scratch.MrgprA3,a m......
Voltage-gated sodium(NaV)channels control the upstroke of the action potentials in excitable cells.Multiple studies have......
The HECT type E3 ligases are key regulators of cell growth and proliferation,and malfunctions of these enzymes are assoc......
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The ERK activation in the local interneurons of spinal dorsal horn is critical for histamine induced
Objective Itch has a significant negative impact on an individuals quality of life.However,the molecular mechanisms unde......
How somatosensory modality-specific information is encoded and represented in the brain remains a fascinating question a......
Despite of the clinical importance,cell surface receptors mediating non-histaminergic itch are largely unknown....
Enhanced scratching elicited by a pruritogen and an algogen in a mouse model of contact hypersensiti
Chemical pruritogens and algogens evoke primarily itch and pain,respectively,when administered to the skin of healthy hu......
The ERK activation in the local interneurons of spinal dorsal horn is critical for histamine induced
Objective Itch have a significant negative impact on an individuals quality of life.However, the molecular mechanisms un......
The contributions of gasotransmitters to itch sensation are largely unknown.In this study, we aimed to investigate the r......
Chronic stress is widely considered to trigger or enhance itch, especially for pruritic dermatitis.However, the molecula......
Specific Patterns of Spinal Metabolite Ratio Underlying a-Me-5-HT-evoked Pruritus Compared with Comp
Mechanisms of pruritus are implicated in the dysregulation of the metabolites in the spinal cord.We investigated pruritu......
Objective:To evaluate the adjuvant treatment of acute stage symptoms and quality of life of patients with bullous pemphi......
Objective· Formalin is a classic and most widely used algogenic substance,but its itchy effect is not clear.The present......
KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion
Acute renal injury(AKI)causes a long-term risk for progressing into chronic kidney disease(CKD)and interstitial fibrosis......
Peripheral inflammation is always accompanied by a noxious sensation,either pain or itch,pro-viding a protective warning......
目的 探讨神阙穴贴敷治疗慢性湿疹,对快速缓解瘙痒,提高患者的舒适和满意率的影响.方法 将68例慢性湿疹患者随机分为实验组38例和......
ITCH又称AIP4(atrophin 1 相互作用蛋白4),最初是在研究小鼠表皮颜色时被发现的.ITCH是一个单体蛋白,属于同源的HECT类型的泛素连......
泛素-蛋白酶体通路是选择性降解蛋白质的重要途径,在细胞分裂调节、DNA修复及肿瘤细胞消除等方面具有重要作用。E3泛素连接酶能够......
Introduction::Pemphigoid nodularis is a rare clinical variant of bullous pemphigoid characterized by both prurigo nodula......
Protein ublquitlnatlon is an important means of posttranslational modification which plays an essential role in the regu......
目的 利用超声介导微泡破裂技术(UTMD)沉默T淋巴细胞Itch基因表达,观察转染T细胞对胃癌MFC细胞的免疫杀伤效率.方法 免疫磁珠分离T......
Itch是新近发现的泛素连接酶E3之一,其参与细胞内多种信号蛋白如PLC-γ、PKC-θ、JunB、notch等的泛素化修饰过程,调控细胞表型及......
旺周湿疹的临床表现包括肛周皮肤出现丘疹，有瘙痒、糜烂、渗液及结痂的现象，且反复发作。自2010年以来，笔者以苦参汤加减外洗坐浴治疗......
肛周湿疹临床表现为肛周皮肤出现丘疹,瘙痒,甚至皮肤糜烂,渗出,结痂,且反复发作。自2010年以来,笔者以苦参汤加减外洗坐浴治疗肛周......
目前认为特应性皮炎发病机制不清,可能具有遗传缺陷的个体,在环境等因素的作用下皮肤的蛋白、脂质等的代谢出现异常,进而出现皮肤......
目的观察H3受体激动剂（R-α-甲基组胺）和拮抗剂（噻普酰胺）对5-羟色胺（5-HT）诱导大鼠搔抓行为的影响,并探讨H3受体在大鼠瘙痒初级传入通路......
目的了解瘙痒性皮肤病的变应原情况.方法应用变应原皮肤点刺试验对5种常见的瘙痒性皮肤病进行检测. 结果 280例瘙痒性皮肤病患者的......
目的观察神经病理性疼痛对瘙痒神经信号转导的影响,探讨瞬时受体电位M8离子通道（TRPM8）在瘙痒-疼痛共病中的作用。方法实验一：将KM雄......
目的 探讨丙戊酸钠（ VPA）对小鼠坐骨神经分支高选择结扎切断 （ SNI）引起的神经病理性疼痛与氯喹诱发的急性瘙痒的影响. 方法 实验一：将......
目的通过Meta分析更全面地概括描绘实验性瘙痒所激活脑区,以更明确瘙痒相关高级中枢处理过程。材料与方法检索Pubmed、Cochrane中......
背景与目的：Itch蛋白是一种具有调节T细胞免疫应答起始的关键分子,属于E3泛素转移酶家族,广泛参与细胞内多种信号蛋白如ZAP70、P85......
目的：探讨抗炎新药Acetamide 45对化合物48／80诱发的皮肤瘙痒的作用机制方法：将ICR小鼠随机分成生理盐水组、模型组（生理盐水＋化合物48／8......
文章从文献角度与医学原理,分析了《素问·至真要大论》＂诸痛痒疮,皆属于心＂一句中的＂痒＂字,对历代医家的理解作疏解,并结合当代学......
笔者对31例低分子右旋糖酐致皮肤瘙痒的病例进行了临床观察,总结了瘙痒的发生与持续时间、好发部位及特点、治疗情况等,并采取针对......
瘙痒动物模型是痒研究中重要且发展较快的领域。动物模型的改进极大促进我们对痒病理机制的了解，且完善了痒治疗的新策略。......
This review highlights recent advances in pathophysiology and treatment for uremic pruritus, especially focusing on vari......
Background: Dry skin induces antihistamine-resistant itch, as well as epidermal hyperinnervation, which is partly respon......
目的利用超声介导微泡破裂技术(UTMD)沉默T淋巴细胞Itch基因表达,观察转染T细胞对胃癌MFC细胞的免疫杀伤效率。方法免疫磁珠分离T......
目的利用超声介导微泡破裂技术(UTMD)沉默T淋巴细胞Itch基因表达,观察转染T细胞对胃癌MFC细胞的免疫杀伤效率。方法免疫磁珠分离T......
