HSCs相关论文
Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/α-KG-m
Hepatic stellate cells(HSCs)play an important role in the initiation and development of liver fibrogenesis,and abnormal ......
Heterozygous lipoprotein lipase knockout mice exhibit impaired hematopoietic stem/progenitor cell co
Background : Hematopoietic stem cells (HSC) maintain the hematopoietic system ho-meostasis through self- renewal and mul......
期刊
Indole-3-propionic Acid-aggravated CCl4-induced Liver Fibrosis via the TGF-β1/Smads Signaling Pathwa
Background and Aims: The pathogenesis of liver fibrosis involves liver damage, inflammation, oxidative stress, and intes......
Platycodon grandiflorum (Jacq.) A.DC.and Panax Ginseng C.A.mey extracts inhibits hepatic fibrosis in
Fibrosis is a phenomenon of fibrous connective tissue increase in the organs.Activated hepatic stellate cells(HSCs) are ......
Direct regulation of p53 by miR-142a-3p mediates the survival of hematopoietic stem and progenitor c
Hematopoietic stem and progenitor cells (HSPCs) have the capacity to self-renew and differentiate into all blood cel......
Hematopoietic stem cells(HSCs) are specified and generated during the embryonic development and have remarkable potentia......
目的:肝纤维化(hepatic fibrosis)是慢性肝损伤的组织代偿性反应,若不及时去除潜在致病因素将会进一步发展为肝硬化甚至肝癌。肝星......
Ligustroflavone ameliorates CCl4-induced liver fibrosis through down-regulating the TGF-β/Smad signa
Liver fibrosis is a pathological process characterized by excess deposition of extracellular matrix (ECM) that are mainl......
目的:研究马兰草脐灸通过线粒体途径促进肝纤维化(hepatic fibrosis,HF)模型大鼠活化肝星状细胞(hepatic stellate cells,HSCs)凋......
肝纤维化的发病机制较为复杂,目前Wnt信号转导通路与肝纤维化的研究引起了广大学者的关注。通过文献查阅综述了Wnt信号在肝纤维化......
研究莪术含药血清抑制活化的大鼠肝星状细胞(hepatic stellate cells,HSCs)中Hedgehog(Hh)信号通路关键因子Shh(sonic hedgehog),G......
肝纤维化是世界范围内高发病率和高死亡率的主要疾病之一,它是各种慢性刺激性疾病如病毒性肝炎、酒精滥用、自身免疫性疾病、代谢......
肝纤维化是世界范围内高发病率和高死亡率的主要疾病之一,它是各种慢性刺激性疾病如病毒性肝炎、酒精滥用、自身免疫性疾病、代谢......
肝纤维化是世界范围内高发病率和高死亡率的主要疾病之一,它是各种慢性刺激性疾病如病毒性肝炎、酒精滥用、自身免疫性疾病、代谢......
肝星状细胞(HSCs)的凋亡在肝纤维化中的作用日益受到人们的重视,其凋亡途径是近年学术界研究的热点.激活的HSCs可自发发生凋亡,可......
肝纤维化是肝硬化进展的早期步骤,感染、毒性/药物诱导,代谢和自身免疫都可以导致肝纤维化。而在肝纤维化的过程中,肝星状细胞(hep......
目的观察丹参含药血清是否可以通过抑制瘦素诱导的刺猬(Hedgehog,Hh)信号通路中纤毛蛋白(Ellis-van creveld syndrome protein 2,E......
目的通过大鼠肝星状细胞（hepatic stellate cells,HSCs）与大鼠脂肪间充质干细胞（rat adipose tissue-derived mesenchymal stem cells......
AIM: To elucidate the mechanism by which somatostatin and its analogue exert the influence on liver fibrosis, and to inv......
Effect of rat serum containing Biejiajian oral liquid on proliferation of rat hepatic stellate cells
AIM: Liver fibrosis is a common pathological process of chronic liver diseases. Activation of hepatic stellate cells(HSC......
AIM: To make drug sera of Salvia miltiorrhiza and Yigankang, both of which are Chinese herbs that activate bleeding and ......
AIM: To investigate the effects of Danshaohuaxian (DSHX),a Chinese herbal recipe, on the apoptosis and cell cycles of he......
目的:研究中药复方制剂丹芍化纤胶囊对体内外活化肝星状细胞(HSCs)增殖的影响.方法:(1)体内实验:雄性Wistar大鼠57只分为正常组、......
目的：观察灯盏花素对肝纤维化的保护作用，探讨其可能的作用机制。方法：大鼠肝星型细胞HSC体外培养观察灯盏花素对成纤维细胞增殖、激......
目的探讨甘草酸对大鼠肝星状细胞（HSC）的氧化应激及核转录因子E2相关因子2（Nrf2）/血红素加氧酶（HO）-1信号通路的影响。方法体外培养HSC细......
目的探究3种丝裂原活化蛋白激酶（MAPK）抑制因子对转化生长因子-β（TGF-β）活化的大鼠肝星状细胞（HSC）中Smad2/3磷酸化及Smad4核转位的影......
肝纤维化是各种慢性肝病的病理基础，Friedman等［1］认为，肝脏损伤-肝实质炎症、坏死-HSCs激活-大量ECM沉积，是其核心环节。静止的HSCs被......
目的：构建携带人源ggpps基因的重组腺病毒并用其研究GGPPS对人肝星状细胞的活化作用.方法：利用PCR方法扩增ggpps基因片段,并亚克隆至......
研究人员已经确立了一种似乎能扩大脐带血中干细胞数目的分子。造血干细胞（HSC）——它能制造每一种血细胞——可在身体的数个地方被......
Investigating the function of combining induced rat monocytes-derived bone marrow-haemopoietic stem cell (rat BM-HSCs) w......
Hepatic fibrosis is a wound-healing response for injury. Activated hepatic stellate cells （HSCs） are the preferred targets......
Platycodon grandiflorum （ Jacq. ） A. mey extracts inhibits hepatic fibrosis DC. and Panax Ginseng C.
Fibrosis is a phenomenon of fibrous connective tissue increase in the organs. Activated hepatic stellate cells （HSCs） are ......
肝纤维化的形成主要是由于肝炎病毒、酒精、药物与毒物、血吸虫、代谢和遗传、胆汁郁积、自身免疫性肝病等多种损伤因素长期慢性刺......
Effects of c-myb antisense RNA on TGF-β1 and α1-Ⅰ collagen expression in cultured hepatic stellate c
AIM: To investigate the effects of c-myb antisense RNA on cell proliferation and the expression of c-myb, TGF-β1 and ......
Effects of endothelin-1 on hepatic stellate cell proliferation, collagen synthesis and secretion, in
AIM: To explore the effects of endothelin-1(ET-1) on hepatic stellate cells (HSCs) DNA uptake, DNA synthesis,collagen sy......
肝纤维化是多种原因导致的慢性肝损伤的共同病理学改变。肝星状细胞（HSCs）活化增殖，转化为肌成纤维细胞是肝纤维化的关键环节。活化的......
目的 分析醛固酮促进肝纤维化作用的机制。方法 大鼠随机分组，四氯化碳溶液造模，干预组同时给予安体舒通灌胃。定期宰杀动物进行相关......
目的:研究中药复方制剂丹芍化纤胶囊对体外活化肝星状细胞(HSCs)增殖、凋亡及Fas蛋白、caspase-3 mRNA表达的影响,探讨该药抗肝纤......
第一部分[目的]探讨AGM时期(E10～E12)小鼠造血部位的解剖结构。[方法]将雌、雄小鼠以3: 1合笼喂养,观察小鼠阴道栓获得准确孕期的小......
目的:构建COX-2过表达载体,并转染至HSC-T6中观察其表达情况,为进一步研究COX-2与HSC生物学功能的关系提供前期准备。方法:1.调取C......
介绍了由中国石化集团洛阳石油化工工程公司工程研究院开发的计算机与现场仪表通信系统HSCS 95的技术结构、技术特点及硬件和软件......
背景和目的:造血干细胞(hematopoietic stem cells,HSCs)具有自我更新和多向分化的潜能,目前很多血液系统恶性疾病有效的治疗方法......
肝纤维化是对慢性肝损伤的愈合反应，为一个可逆的过程.鉴于肝星状细胞（HSCs）在肝纤维化发病机制中的主导作用，大多数抗肝纤维化研究都......
观察丹参含药血清对瘦素刺激的大鼠肝星状细胞(hepatic stellate cell,HSCs)丝氨酸/苏氨酸蛋白激酶抑制剂(Su Fu)和双特异性酪氨酸......
越来越多研究证据表明,白血病起始细胞(LICs)或者白血病干细胞(LSCs)是白血病发生、发展以及复发的关键因素。因此,寻找LICs的特异......
