DRUGRESISTANCE相关论文
PRPS2 mutations drive acute lymphoblastic leukemia relapse through influencing PRPS1/2 hexamer stabi
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嵌合抗原受体T细胞（CAR-T）在恶性血液肿瘤治疗中取得了突破性成果，但耐药与复发限制了其广泛应用。第63届美国血液学会年会上针对CAR-......
Mantle cell lymphoma(MCL)is a lymphoproliferative disorder lacking reliable therapies.PI3K pathway contributes to the pa......
Encoded by PTPN11,the SHP2(Src homology-2 domain-containing protein tyrosine phosphatase-2)is widely recognized as a car......
目的 分析我院肝硬化患者腹水培养阳性标本中的病原菌分布及耐药情况.方法 对我院2016年1月至2020年12月间所送检肝硬化患者的901......
Theoretical Investigating Mechanisms of Drug-Resistance Generated by Mutation-Induced Changes in Inf
Influenza A (A/HxNy) is a signif-icant public health concern due to its high infectiousness and mortality.Neuraminidase,......
结核病是全世界致死率较高的传染病之一，特别是耐药结核病的存在加重了全球疾病负担。儿童作为结核患者中的特殊群体，其临床症状不典......
Synergistic effects of methyl 2-cyano-3,11-dioxo-18beta-olean-1,-12-dien-30-oate and erlotinib on er
Non-small cell lung cancer (NSCLC) is often characterized by an underlying mutation in the epidermal growth factor recep......
目的:研究本地区临床分离铜绿假单胞菌(Pseudomonas aeruginosa,PA)的感染分布情况,并对常用抗生素的耐药特征分析,为医院感控提供......
Continuous docetaxel (DTX) treatment of non-small cell lung cancer induces development of drug resistance,but the mechan......
Background:One of the challenges in personalized medicine is to determine specific drugs and their dosages for patient i......
Cancer cells are often exposed to cell intrinsic stresses and environmental perturbations that may lead to accumulation ......
目的:探讨热疗对人喉癌Hep-2顺铂耐药（Hep-2/CDDP）细胞株生物学行为的影响和可能机制。方法:采用高浓度冲击联合浓度递增法诱导建立H......
目的:探讨血液科住院患者继发感染的细菌分布及耐药情况。方法:回顾性分析2015年1月至2019年12月徐州医科大学附属医院血液科1 125......
肾母细胞瘤(n WT)n 1基因位于人类染色体11p13，其编码的WT1具有抑制肿瘤生长与激活癌基因转录的双重功能，是一个双向转录因......
Combination therapy with miR34a and doxorubicin synergistically inhibits Dox-resistant breast cancer
Resistance to breast cancer(BCa)chemotherapy severely hampers the patient\'s prognosis.MicroRNAs provide a potential t......
Exosomes are cell-derived nanovesicles with diameters from 30 to 150 nm,released upon fusion of multivesicular bodies wi......
Wenxia Changfu Formula(温下肠腑方) Induces Apoptosis of Lung Adenocarcinoma in A Transplanted Tumor Model
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GL-V9 reverses adriamycin resistance in hepatocellular carcinoma cells by affecting JNK2-related aut
Adriamycin resistance in HCC seriously hinders the treatment of patients,it is necessary to investigate the mechanisms.A......
Current opinion and mechanistic interpretation of combination therapy for castration-resistant prost
Recent advances in genomics technology have led to the massive discovery of new drug targets for prostate cancer;however......
Dynamic changes and surveillance function of prion protein expression in gastric cancer drug resista
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The emergence of drug-resistant cancer cells together with the toxicity side effect of chemotherapy agents are the major......
Site-specific drug-releasing polypeptide nanocarriers with enhanced therapeutic efficacy against dru
Repeated administration of chemotherapeutic agents leads to drug resistance of the tumors,which significantly hinders dr......
Multifunctional nanoparticle complexes-mediated drug and oxygen co-delivery to overcome drug resista
Accumulating evidences illustrate that hypoxia is an common microenvironment characteristic in tumor,which is involved i......
Multidrug resistance(MDR)was one of the major obstacles to the effective cancer chemotherapy.The mechanisms about MDR wa......
Combating Drug Resistance in hepatocellular carcinoma cells through inhibition of ABC family protein
Multidrug resistance is an unavoidable obstacle in the development of anticancer research.Platinum(Pt)based complexes ha......
Dual-sensitive charge-conversional polymeric prodrug for efficient co-delivery of demethylcantharidi
Tumor is a complicated system,and tumor cells are typically heterogeneous in many aspects[1].Polymeric drug delivery nan......
Over-expression of miR-206 decreases the Euthyroxresistance by targeting MAP4K3 in papillary thyroid
目的 microRNAs(miRNAs)play a critical role in drug resistance of multiple cancersincluding papillary thyroid carcinoma(P......
knockdown of Retinoic Acid Receptor α expression suppresses the tumorigenicity of pancreatic carcino
Objective Retinoic acid receptor α(RARα),a member of retinoic acid receptors subfamily,takes part in many key processe......
Expression and Clinical Significance of Methyl-CpG Binding Domain Protein2in High-grade Serous Ovari
目的 The expression of methyl-CpG binding domain protein 2(MBD2)in high-grade serous ovarian cancer(HGSOC)tissues and it......
Integrative PDGF/PDGFR and focal adhesion pathways are downregulated in ERCC1-defective non-small ce
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Antibiotic resistance and risk factors of patients with pneumonia caused by tracheotomy in radiother
Objective Background: Elective tracheostomy is a common procedure used in patients with head and neck cancer.However,pne......
Objective Non-Hodgkin lymphomas(NHL)are lymphoproliferative malignancies that encompass different biologic and histologi......
Cul4 E3 Ubiquitin Ligase Regulates Ovarian Cancer Drug Resistance by Targeting the Anti-apoptotic Pr
Objective Purpose: The failure of cancer chemotherapy is mostly caused by the development of drug resistance.In addition......
IGF2BP3 promotes the oncogenesis and progression of colorectal cancer and mediate cetuximab resistan
Objective The molecular mechanism of the occurrence and progression of colorectal cancer is very complex,which includes ......
Objective: To explore the expressions of AnnexinA2 in the bladder cancer cell lines and bladder cancer tissues.We want t......
DNA methyltransferase 3A(DNMT3A)regulates cisplatininduced cell apoptosis and contributes to chemore
目的 Cisplatin is widely used in the treatment of several solid malignant tumors,including gastric cancer(GC).However,ge......
MEK2 is a prognostic marker and potential chemo-sensitizing target for glioma patients undergoing te
Objective While temozolomide is the first-line chemotherapeutic agent against glioblastoma,its oftennon-curative due to ......
Analysis of pathogenic bacteria resistance and risk factors for death on 95 cases of elderly emergen
Objective To analyze the clinical characteristics of ventilator-associated pneumonia (VAP) in patients admitted by emerg......
ClC-3 is a member of the voltage-gated chloride channel superfamily.It has been suggested by us and others to be closely......
Clitocine induces drug-resistant cancer cells apoptosis in vitro through repression of Mcl-1 and gro
Clitocine is an amino nucleoside that has been shown to inhibit human cancer cell proliferation.Here, we reported that C......
In traditional chemotherapy,limited drug permeation and retention at tumor site,as well as the acquired multi-drug resis......
Sericin nanomicelles with enhanced cellular uptake and pH-triggered release of doxorubicin reverse c
Objective To explore the synthetic method of a nanomicelle(sericin-PBLG-DOX),and the mechanism of reversing cancer drug ......
Vitamin B12(VB12)-conjugated sericin micelles for targeting gastric cancer and reversing drug resist
Objective To explore the synthesis procedures of Vitamin B12-modified sericinencapsulated PTX micelles,we refer to these......
Genetic Diversity and Drug Resistance Among Antiretroviral Treatment-Failed Individuals From 2010 to
Background:The most common antiretroviral treatment(ART)received by individuals infected with HIV-1 in China is the comb......
Molecular basis of eIF3a action in therapeutic response of lung cancer patients to platinum-based ch
eIF3a is the largest subunit of eukaryotic translation initiation factor 3 (eIF3) that has been suggested to play a role......
Ps-07081 Clinical study on Km gene mutation in mycobacterium tuberculosis strains isolated from pulm
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A non-negligibly representative non-tumor cells-tumor associated fibroblast cells(CAFs)has a very important effect on tu......
