D-Serine相关论文
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Objective: The present study was aimed to observe the effects of D-serine on the learning and memory functions of the MK......
Purposes Convincing data demonstrate that serine racemase(SR)and its product,D-serine contribute to excitotoxicity.A lin......
Multiple glial-neuronal dialogues in morphine tolerance:role of P2X7 receptor downstream cascades in
Objective Morphine is a potent analgesic.However, its clinical application is restricted due to morphine tolerance.The u......
Aims More and more advances show that hydrogen sulfide (H2S) sulfhydrates functional proteins and regulates their action......
The NMDA receptor co-agonist D-serine ameliorates emotional and cognitive impairment in polyI:C-trea
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Corticosterone induced D-serine release deficit play an important role in long-term potentiation imp
OBJECTIVE Previous studies showed that over activation of NMDA receptors may be a crucial cause of long-term potentiatio......
Parvalbumin interneurons in anterior cingu⁃late cortex regulate cognitive behaviors in methylazoxyme
OBJECTIVE Cognitive dysfunc⁃tion is a core disturbance of schizophrenia,appear to emerge from impaired neural activity.......
目的通过观察砷对星形胶质细胞(AST)分泌D-丝氨酸的影响,探讨砷的智力损伤作用机制。方法以原代培养脑AST为试验对象,在含砷浓度分......
目的:观察D-serine合成相关的丝氨酸消旋酶(SR)在大鼠和癫痫病人海马组织的分布与细胞定位特点。方法:成年和幼龄SD大鼠灌流固定、......
Although exogenous D-serine has been applied as a neural regulatory intervention in many studies, the role played by D-s......
AIM: To study the alterations of the expressions of serine racemase in C57BL/6 mouse brain after permanent focal cerebra......
,In vitro and in vivo activity of D-serine in combination with β-lactam antibiotics against methicil
As D-amino acids play important roles in the physiological metabolism of bacteria,combination of D-amino acids with anti......
目的 观察D-丝氨酸与奎硫平联合治疗谷氨酸功能低下精神分裂症(SZ)模型小鼠的效果,为临床治疗提供实验依据.方法 使用昆明种小鼠做......
以D-丝氨酸为起始原料,经酯化、酰胺化、氨解、环合、水解脱保护基五步反应合成D-环丝氨酸,反应总收率48.0%。目标产物化学结构经......
目的：研究Ｄ－丝氨酸对大鼠小脑ＮＭＤＡ受体／ＮＯ／ｃＧＭＰ神经通种的调节作用。方法：采用清醒大鼠脑微透析技术，应用放免方法测定小脑透析液中ｃＧＭＰ含量。结果：小脑内......
手术后认知功能障碍（postoperativecognitivedysfunction，POCD）是手术后老年患者常见的中枢神经系统并发症。临床表现为精神错乱、焦......
采用高效毛细管电泳一非接触电导检测法，使用未涂层石英毛细管（50μmi．d．×45cm，Leff=40cm），以3．2mmol／L氢氧化钠＋0．4mmol／L柠檬酸＋2．5mmol／L......
Aims More and more advances show that hydrogen sulfide （H2S） sulfhydrates functional proteins and regulates their actions.......
Although exogenous D-serine has been applied as a neural regulatory intervention in many studies,the role played by D-se......
S1A-5 Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects Aga
The unbalance between synaptic(GluN2A,mediating the protective pathway)and extrasynaptic NMDA receptors(NMDARs)(GluN2B,m......
目的:研究外源性D-serine对吗啡成瘾的作用以及可能的机制。方法:首先多次吗啡注射构建大鼠成瘾性模型,采用条件性位置偏爱实验检......
