搜索筛选:
搜索耗时1.4509秒,为你在为你在102,285,761篇论文里面共找到 21 篇相符的论文内容
发布年度:
[会议论文] 作者：Lingzi Zhang,Peng Zhan,Christophe Pannecouque,Xinyong Liu,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Benzophenone derivatives(BPs),such as GW678248 and GW4511,have been reported as a class of HIV-1 NNRTIs with excellent potency against a broad panel of wild type and resistant mutant strains[1,2]....
[期刊论文] 作者：Chunlin Zhuang,Christophe Pannecouque,Erik De Clercq,Fener Chen,
来源：药学学报（英文版） 年份：2020
Human immunodeficiency virus (HIV) is the primary infectious agent of acquired immunodeficiency syndrome (AIDS),and non-nucleoside reverse transcriptase inhibit...
Design,synthesis,and biological investigation of new C6-rigid S-DABOs as Non-nucleoside HIV-1 revers
[会议论文] 作者：Hai-Qiu Wu,Qiu-Qin He,Fen-Er Chen,Erik De Clercq,Jan Balzarini,Christophe Pannecouque,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
A series of C6-rigid S-DABO analogs featured with a substituted benzoyl group at C6 position of the pyrimidine ring has been designed,synthesized and biolog...
[期刊论文] 作者：Sheng Han,Yuan Lei,Christophe Pannecouque,Erik De Clercq,Chunlin Zhuang,Fener Chen,
来源：中国化学快报（英文版） 年份：2020
Two series of sulfur-containing diarylbenzopyrimidines are designed by the fragment combination of a thioacetamide with our previous disclosed DABP 3 and furthe...
Synthesis and Biological Evaluation of New Conformationally Restricted S-DABO Hybrids as Non-nucleos
[会议论文] 作者：Hai-Qiu Wu,Qiu-Qin He,Fen-Er Chen,Christophe Pannecouque,Dirk Daelemans,Erik De Clercq,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
A series of conformationally restricted S-DABO hybrids combined the structural features of α-methyl-S-DABOs and CN-S-DABOs has been synthesized and biologically evaluated for their anti-HIV activity a...
Design,synthesis,and biological investigation of new C6-rigid S-DABOs as Non-nucleoside HIV-1 revers
[会议论文] 作者：Hai-Qiu Wu,Qiu-Qin He,Fen-Er Chen,Erik De Clercq,Jan Balzarini,Christophe Pannecouque,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
A series of C6-rigid S-DABO analogs featured with a substituted benzoyl group at C6 position of the pyrimidine ring has been designed,synthesized and biologically evaluated as NNRTIs against wild type...
[会议论文] 作者：Gu,Shuang-Xi,Zhu,Yuan-Yuan,Chen,Fen-Er,Erik De Clercq,Jan Balzarini,Christophe Pannecouque,
来源：中国化学会第八届有机化学学术会议暨首届重庆有机化学国际研讨会 年份：2013
...
[期刊论文] 作者：万正勇,陈芬儿,Erik De Clercq,Dirk Daelemans,Christophe Pannecouque,,
来源：中国科学:化学 年份：2015
我们以已上市的etravirine和正在临床研究的VRX-480773两个逆转录酶抑制剂为模板,通过杂交这两个化合物的药效团,获得含酰胺片段的S-DAPYs类似物,该类似物对野生型HIV-1病毒株具有中等强度抑制活性.而Maurizio所发现的另一类无酰胺片段的S-DAPYs类似物却表现出......
Discovery of Fused Bicyclic Heteroaromatic Thioacetanilides as Potent HIV-1 Inhibitors Using a Scaff
[会议论文] 作者：Xiao Li,Peng Zhan,Erik De Clercq,Jan Balzarini,Christophe Pannecouque,Xinyong Liu,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
In continuation of our efforts toward the discovery of potent HIV-1 NNRTIs with novel structures [1,2],we have employed a scaffold hopping strategy [3] to explore the chemically diverse space of bioac...
,Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazin
[期刊论文] 作者：Kaijun Jin,Minjie Liu,Chunlin Zhuang,Erik De Clercq,Christophe Pannecouque,Ge Meng,Fener Chen,
来源：药学学报（英文版） 年份：2020
In order to improve the positional adaptability of our previously reported naphthyl diaryltria-zines (NP-DATAs),synthesis of a series of novel biphenyl-substitu...
[期刊论文] 作者：熊远珍,胡海荣,陈芬儿,Jan Balzarini,Christophe Pannecouque,Erik De Clercq,,
来源：药学学报 年份：2009
在已有工作基础上,基于分子对接设计合成了8个新的4-烯丙基取代和4-叠氮基取代的二芳基三嗪类衍生物。抗HIV-1活性的测试结果表明所有新化合物均具有抗HIV-1活性。其中化合物...
[会议论文] 作者：Zi-Hong Yan,Hai-Qiu Wu,Qiu-Qin He,Fen-Er Chen,Erik De Clercq,Jan Balzarini,Christophe Pannecouque,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
A series of novel diarylpyrimidine with a halogen substituent on the methylene linker between wing I and the central pyrimidine were synthesized and evaluated for their anti-HIV activity in MT-4 cell...
Design,synthesis and anti-HIV activities of novel diarylpyrimidines with highly flexible diatomic li
[会议论文] 作者：Shuang-Xi GU,Heng QIAO,Yuan-Yuan ZHU,Xiu-Lian JU,Erik DE CLERCQ,Jan BALZARINI,Christophe PANNECOUQUE,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Non-nucleoside reverse transcriptase inhibitors(NNRTIs)have received wide attention due to their unique antiviral potency,high specificity and low cytotoxicity[1]....
Structure-based Bioisosterism Design,Synthesis and Biological Evaluation of Novel 1,2,4-Triazin-6-yl
[会议论文] 作者：Peng Zhan,Xiao Li,Xuwang Chen,Ye Tian,Wenmin Chen,Xinyong Liu,Christophe Pannecouque,Erik De Clercq,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
The development of new HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) offers the possibility of generating novel chemical entities of increased potency [1-5].Previous investigations in...
[会议论文] 作者：Peng Zhan,Xiaofei Jiang,Wenmin Chen,Xuwang Chen,Ye Tian,Xinyong Liu,Christophe Pannecouque,Erik De Clercq,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
In order to expand the structure-activity relationship(SAR) studies on arylazolylthioacetanilide NNRTIs [1-14],based on the structure-based bioisosterism principle,a series of novel 2-(5-(naphthalen-1...
[会议论文] 作者：Ping Gao,Xiqiang Cheng,Lin Sun,Christophe Pannecouque,Erik De Clercq,Luis Menéndez-Arias,Xinyong Liu,,
来源：中国化学会第十届全国无机化学学术会议 年份：2019
...
[会议论文] 作者：Xinyong Liu,Peng Zhan,Xuwang Chen,Wenmin Chen,Ye Tian,Xiao Li,Christophe Pannecouque,Jan Balzarini,Erik,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
Aquired Immune Deficiency Syndrome(AIDS) caused by human immunodeficiency virus(HIV),is still prevalent worldwide.The most efficient and standard treatment regimen for HIV-1 infection,namely as highly...
Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrim
[期刊论文] 作者：Li,Chunsheng Zhang,Wei Ding,Siming Huang,Le Yu,Nan Lu,Wenkai Pan,Yiming Li,Erik De Clercq,Christophe Pannecouque,
来源：中国化学快报：英文版 年份：2021
In continuation of our efforts toward the discovery of potent HIV-1 NNRTIs with diverse structures,a series of novel S-DACO analogues of 6-(2-cyclohexyl-1-allkyl)-2-(2-oxo-2-phenyl-ethylsulfanyl)pyrimidin-4(3 H)-ones were designed,synthesiz......
Boronic acid-containing diarylpyrimidine derivatives as novel HIV-1 NNRTIs:Design, synthesis and bio
[期刊论文] 作者：,Fenju Wei,Yanying Sun,Prem Prakash Sharma,Tao Zhang,Hao Lin,Brijesh Rathi,Erik De Clercq,Christophe Pannecouque,
来源：中国化学快报（英文版） 年份：2021
Drug resistance remains to be a serious problem with type I human immunodeficiency virus (HIV-1) non-nucleoside reverse transcriptase inhibitors (NNRTIs). A series of novel boronic acid-containing diarylpyrimidine (DAPY) derivatives were de......
,Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted t
[期刊论文] 作者：Tiziana Ginex,Jinmi Zou,Fenju Wei,Tong Zhao,Boshi Huang,Yanying Sun,Samuel Desta,Erik De Clercq,Christophe Pannecouque,
来源：药学学报（英文版） 年份：2020
In this report,a series of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives were designed to explore the hydrophobic channel of the non-nucle...
相关搜索：
