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本文以金属络合物化学的观点,分别从金属离子、金属络合物,致癌剂及抗癌剂的络合形成能方面提出金属离子与致癌及抗癌的密切关系。一、由金属引起的致癌想到Mn,Fe,Ce,Cu,Zn,V,Cr,Mb,W,Nb,Gd,Se等为生物界必须的微量元素,以及全部酶的30％以金属酶的形式存在,故认为金属元素与癌有某些关连是很自然的。从历史来看,癌与金属元素的关连,正作为职业癌被发现出来。例如,从事Cr、Hi等工人多肺癌,Pb多引起脑癌。据最近报告,作为与Ni有关的致癌物的有:Ni_3S_2、NiO、NiCO_3、Ni(CH_3COO)_2、Ni(环—戊二烯)2及金属镍。而且[Ni(CO)_4)在实验动物中已查叨它有很强的致癌性。
In this paper, the metal complex chemical point of view, respectively from the metal ions, metal complexes, carcinogens and anticancer agents complex formation energy put forward metal ions and carcinogens and anticancer closely. First, the carcinogens caused by metal Think of Mn, Fe, Ce, Cu, Zn, V, Cr, Mb, W, Nb, Gd, Se and other trace elements necessary for the biological world, and 30% Form exists, so that some metal and cancer have a natural connection is very natural. Historically, the link between cancer and metal elements is being discovered as occupational cancer. For example, workers engaged in Cr, Hi and other lung cancer, Pb and more cause brain cancer. According to recent reports, Ni-3S 2, NiO, NiCO 3, Ni (CH 3 COO) 2, Ni (cyclopentadienyl) 2 and metallic nickel have been reported as carcinogens related to Ni. Moreover, [Ni (CO) _4) has been investigated in laboratory animals for its strong carcinogenicity.