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目的：观察梗阻性黄疸病人术前抗内毒素治疗对内毒素血症抑制及ＩＬ－６、ＩＬ－８的影响。方法：梗阻性黄疸病人分３组在术前分别给予一般手术治疗（ＯＪ组），口服胆盐（ＯＪＴ１组）和静脉注射抗内毒素抗体（ＯＪＴ２组）观察血浆内毒素（ＥＴ）、ＩＬ－６及ＩＬ－８含量变化。结果：３组术前ＥＴ、ＩＬ－６和ＩＬ－８水平差异不显著。ＯＪＴ１组和ＯＪＴ２组用药后血浆ＥＴ水平均显著下降，明显低于ＯＪ组（Ｐ＜０．０１），术后进一步降低。ＩＬ－６在术后１４ｄ显著降低（Ｐ＜０．０１），ＩＬ－８在术后７ｄ降低（Ｐ＜０．０５）。结论：术前应用胆盐和抗内毒素抗体可有效降低梗阻性黄疸病人围手术期血浆ＥＴ、ＩＬ－６及ＩＬ－８水平。
Objective: To observe the effect of pretreatment anti-endotoxin therapy on the inhibition of endotoxemia and IL-6, IL-8 in patients with obstructive jaundice. Methods: The obstructive jaundice patients were divided into 3 groups: general operation group (OJ group), oral bile salt group (OJT1 group) and intravenous anti-endotoxin antibody (OJT2 group) 6 and IL-8 content changes. Results: There was no significant difference in the levels of ET, IL-6 and IL-8 between the three groups before operation. The levels of plasma ET in OJT1 group and OJT2 group decreased significantly, which were significantly lower than those in OJT group (P <0.01) and further decreased after operation. IL-6 decreased significantly on the 14th postoperative day (P <0.01), IL-8 decreased on the 7th postoperative day (P <0.05). Conclusion: Preoperative application of bile salts and anti-endotoxin antibodies can effectively reduce the levels of plasma ET, IL-6 and IL-8 in patients with obstructive jaundice during perioperative period.