目的　探讨病灶切除联合灶皮质横纤维热灼术治疗顽固性继发癫的效果。方法　对病灶切除联合热灼组与病灶及周围非功能区灶皮质切除组的疗效随访 2 .5～ 5 .5年 ,平均 4 .0年 ,并进行比较。结果　病灶切除联合热灼组效果明显优于病灶及周围非功能区灶皮质切除组 ,两组存在显著性差异(P <0 .0 1)。同时 ,病灶切除加热灼无永久性术后并发症。结论　病灶切除联合皮质灶热灼术是治疗顽固性继发癫安全有效的创新方法 ,远期疗效尚需进一步观察 Objective To investigate the effect of focal resection combined with cortical transverse fiber cauterization on intractable secondary epilepsy. Methods The curative effect of focal resection combined with thermal cauterization and lesions and surrounding non-functional fascia cortex resection were followed up for 2.5-5.5 years with an average of 4.0 years and compared. Results The results of resection combined with thermal cauterization were significantly better than those of lesions and peripheral non-functional aponeurosis. There was significant difference between the two groups (P <0.01). At the same time, focal resection heating without permanent postoperative complications. Conclusions Lesion resection combined with cortical stovepisis is an innovative and safe method for the treatment of refractory secondary epilepsy. The long-term curative effect needs further observation