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目的探讨小儿哮喘采用孟鲁司特钠(顺尔宁)联合布地奈德治疗的效果及对外周血嗜酸性粒细胞的影响。方法 84例哮喘患儿,随机分为对照组和观察组,各42例。在常规治疗的基础上,对照组采用布地奈德治疗,观察组采用顺尔宁联合布地奈德治疗。对比两组疗效、治疗前后肺功能指标和外周血嗜酸性粒细胞(Eos)水平。结果观察组总有效率为97.62%,高于对照组的80.95%(P<0.05);观察组治疗后第一秒用力呼气容积(FEV1)、用力肺活量(FVC)高于对照组,Eos低于对照组(P<0.05)。结论小儿哮喘采用顺尔宁联合布地奈德治疗可明显提高疗效,改善肺功能,降低外周血嗜酸性粒细胞水平。
Objective To investigate the effect of montelukast sodium combined with budesonide on pediatric asthma and its effect on peripheral blood eosinophils. Methods Eighty-four asthmatic children were randomly divided into control group and observation group, with 42 cases in each group. On the basis of routine treatment, the control group was treated with budesonide, and the observation group was treated with sotalol and budesonide. The curative effect of two groups were compared, the indexes of pulmonary function before and after treatment and the level of eosinophil (Eos) in peripheral blood were measured. Results The total effective rate in the observation group was 97.62%, which was higher than that in the control group (80.95%, P <0.05). FEV1, FVC in the observation group were significantly higher than those in the control group In the control group (P <0.05). Conclusion Pediatric asthma with Salbutamol combined with budesonide treatment can significantly improve the efficacy, improve lung function and reduce the level of peripheral blood eosinophils.