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目的研究硝苯地平对妊娠高血压患者母婴结局及脐动脉血流的影响。方法 70例妊娠高血压患者,随机分为对照组(行单纯硫酸镁治疗)和观察组(在对照组基础上加用硝苯地平),每组35例。观察两组治疗后母婴结局及脐动脉血流变化情况。结果观察组治疗总有效率为97.14%,高于对照组的82.86%,差异具有统计学意义(P<0.05)。观察组早产、新生儿呼吸窘迫、胎盘剥离及新生儿死亡发生率低于对照组,差异具有统计学意义(P<0.05)。两组血粘度、红细胞压积、阻力指数(RI)及脐动脉舒张压血流峰速比值(S/D)均低于治疗前,观察组治疗后低于对照组,差异均具有统计学意义(P<0.05)。结论硝苯地平可显著改善妊娠高血压患者脐动脉血流状况,改善母婴结局,具有重要的临床价值。
Objective To investigate the effect of nifedipine on maternal and infant outcome and umbilical artery blood flow in patients with pregnancy induced hypertension. Methods Seventy patients with pregnancy induced hypertension were randomly divided into control group (treated with simple magnesium sulfate) and observation group (nifedipine added on the basis of control group), 35 cases in each group. After treatment, maternal and child outcomes and changes of umbilical artery blood flow were observed. Results The total effective rate of observation group was 97.14%, which was higher than 82.86% of control group, the difference was statistically significant (P <0.05). The incidence of preterm birth, neonatal respiratory distress, placental abruption and neonatal death in the observation group was lower than that in the control group, with statistical significance (P <0.05). The blood viscosity, hematocrit, resistance index (RI) and umbilical artery diastolic blood flow velocity ratio (S / D) of the two groups were lower than those before treatment, the observation group was lower than the control group after treatment, the differences were statistically significant (P <0.05). Conclusion Nifedipine can significantly improve umbilical artery blood flow in patients with pregnancy-induced hypertension and improve maternal and infant outcomes, which has important clinical value.