本文研究了８名健康志愿者单剂口服索他洛尔１６０ｍｇ后药代动力学，用高效液相色谱法测定血清和尿样中索他洛尔浓度，结果表明：药代动力学呈二室模型，Ｔｌａｇ０．３３±０．１０ｈ，Ｔｍａｘ３．３８±０．６９ｈ，Ｃｍａｘ１．６２±０．３２ｍｇ／ｌ，ＡＵＣ１６．２±３．１ｍｇ·ｈ￣（－１）·Ｌ￣（－１），Ｔ＿（１／２）β１４．２±５．０ｈ，Ｖｄ３．６４±１．３５ｌ／ｋｇ，ＣＬ１６９．２±２８．８ｍｌ／ｍｉｎ，我国索他洛尔药代动力学与西方人近似，具有生物利用度较高、表观分布容积较大以及半衰期较长的特点，而且无性别之间的显著差异． This study investigated the pharmacokinetics of 160 mg single dose oral sotalol in eight healthy volunteers and the determination of sotalol in serum and urine samples by high performance liquid chromatography. The results showed that the pharmacokinetics of sotalol in two healthy volunteers were as follows: Model, Tlag0.33 ± 0.10h, Tmax3.38 ± 0.69h, Cmax1.62 ± 0.32mg / l, AUC16.2 ± 3.1mg · h ~ (-1) · L ~ (-1) T 1/2 (1/2) β14.2 ± 5.0h, Vd3.64 ± 1.35l / kg, CL169.2 ± 28.8ml / min, the sodalol pharmacokinetics in China is similar to that of western people, Higher utilization, larger apparent volume of distribution and longer half-life, and no significant difference between the sexes.