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目的对2010~2013年湖北省通城县人民医院19 122名孕妇产前筛查情况进行回顾性分析。方法 2010年10月~2013年10月产检孕妇共19 122例,采用多标记时间分辨免疫分析法检测孕中期女性血清游离人绒毛膜促性腺激素β亚基(Free-β-h CG)及甲胎蛋白(AFP)水平,计算神经管缺陷(NTD)、18-三体综合征及唐氏综合征的发病风险概率。结果 19 122例孕中期孕妇中检测高风险孕妇1 150例(6.01%),其中唐氏综合征933例(4.88%)、NTD 120例(0.63%)、18-三体综合征97例(0.51%)。高风险孕妇中异常孕妇64例(5.57%),低风险孕妇中异常孕妇124例(0.69%),差异有统计学意义(P<0.05)。结论产前孕中期二联筛查对胎儿NTD及染色体异常具有临床实用价值,可降低先天性缺陷患儿的出生率,确保优生。
Objective To retrospectively analyze the prenatal screening of 19 122 pregnant women in Tongcheng People’s Hospital of Hubei Province from 2010 to 2013. Methods A total of 19 122 pregnant women were examined from October 2010 to October 2013. Free-β-hCG and free Aβ mRNA were detected by multi-marker time-resolved immunoassay in pregnant women. Fetoprotein (AFP) levels and calculate the risk of developing neural tube defects (NTD), trisomy 18 and Down’s syndrome. Results A total of 11 122 pregnant women (6.01%) with high risk of pregnancy were enrolled in 19 122 pregnant women, including 933 (4.88%) with Down Syndrome, 120 with NTD (0.63%), 97 with trisomy 18 %). There were 64 pregnant women (5.57%) in high risk pregnant women and 124 pregnant women (0.69%) pregnant women in low risk pregnant women, the difference was statistically significant (P <0.05). Conclusion The prenatal screening in the second trimester of pregnancy on fetal NTD and chromosomal abnormalities with clinical practical value, can reduce the birth rate of children with congenital defects, to ensure that eugenics.