This paper presented a new classified real-time flood forecasting framework by integrating a fuzzy clustering model and neural network with a conceptual hydrological model. A fuzzy clustering model was used to classify historical floods in terms of flood peak and runoff depth, and the conceptual hydrological model was calibrated for each class of floods. A back-propagation (BP) neural network was trained by using real-time rainfall data and outputs from the fuzzy clustering model. BP neural network provided a rapid on-line classification for real-time flood events. Based on the on-line classification, an appropriate parameter set of hydrological model was automatically chosen to produce real-time flood forecasting. Different parameter sets was continuously used in the flood forecasting process because of the changes of real-time rainfall data and on-line classification results. The proposed methodology was applied to a large catchment in Liaoning province, China. Results show that the classified framework provided a more accurate prediction than the traditional non-classified method. Furthermore, the effects of different index weights in fuzzy clustering were also discussed. This paper presented a new classified real-time flood forecasting framework by integrating a fuzzy clustering model and neural network with a conceptual hydrological model. A fuzzy clustering model was used to classify historical floods in terms of flood peak and runoff depth, and the conceptual hydrological BP back-propagation (BP) neural network was trained by using real-time rainfall data and outputs from the fuzzy clustering model. BP neural network provided a rapid on-line classification for real-time flood events. Based on the on-line classification, an appropriate parameter set of hydrological model was automatically chosen to produce real-time flood forecasting. Different parameter sets was continuously used in the flood forecasting process because of the changes of real-time rainfall data and on-line classification results. The proposed methodology was applied to a large catchment in Liaoning province, China. Results show that the classified framework provided a more accurate prediction than the traditional non-classified method. Furthermore, the effects of different index weights in fuzzy clustering were also discussed.