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目的 探讨CD44V6在肺鳞癌中的表达及其与肺鳞癌发生发展的相关性。方法 应用免疫组织化学ABC法检测 35例手术切除的新鲜肺鳞癌组织及其癌旁正常肺组织的CD44V6蛋白 ,并将检测结果与患者的临床病理资料进行对照分析。结果 CD44V6在肺鳞癌组织中的阳性表达率为 6 5 .7% ( 2 3/ 35 ) ,而在癌旁正常肺组织中则无表达 ,二者差异有显著性 ( χ2 =34.3 ,P <0 .0 1) ;CD44V6在有淋巴结转移的肺鳞癌组织中的阳性表达率 ( 84.2 % ,16 / 19)明显高于其在无淋巴结转移者中的阳性表达率 ( 4 3 .8% ,7/ 16 ) ( χ2 =6 .3 ,P <0 .0 1) ;CD44V6阳性表达率随肺鳞癌组织分化程度的降低而升高 ,但无统计学意义 ( χ2 =2 .33 ,P >0 .0 5 ) ;CD44V6在Ⅲ +Ⅳ期肺鳞癌中的阳性表达率 ( 86 .7% ,13/ 15 )明显高于其在Ⅰ +Ⅱ期中的阳性表达率 ( 5 0 % ,10 /2 0 ) ( χ2 =5 .1,P <0 .0 1) ;CD44V6阳性表达患者的 3年生存率 ( 30 .4% ,7/ 2 3)明显低于CD44V6阴性者 ( 6 6 .7% ,8/ 12 ) ( χ2 =4.2 ,P <0 .0 5 )。结论 CD44V6可能与肺鳞癌的发生有关 ;CD44V6阳性预示肺鳞癌可能发生淋巴结转移 ,并对肺鳞癌的临床分期起到一定作用 ;CD44V6阳性还可作为评估肺鳞癌患者预后的参考指标
Objective To investigate the expression of CD44V6 in lung squamous cell carcinoma and its correlation with the occurrence and development of lung squamous cell carcinoma. Methods Immunohistochemical ABC method was used to detect CD44V6 protein in 35 cases of freshly resected lung squamous cell carcinoma tissue and adjacent normal lung tissue. The results were compared with the clinicopathological data of the patients. Results The positive expression rate of CD44V6 in squamous cell carcinoma of lung was 65.7% (23/35), while it was not expressed in para-tumor normal lung tissue. The difference between the two was significant ((2 = 34.3, P < The positive expression rate of CD44V6 in lung squamous cell carcinoma with lymph node metastasis (84.2%, 16/19) was significantly higher than its positive expression rate in those without lymph node metastasis (43.8%, 7/16) (χ2=6.3, P<0. 01); The positive rate of CD44V6 increased with the degree of differentiation of lung squamous cell carcinoma, but it was not statistically significant (χ2 = 2.33, P > The positive expression rate of CD44V6 in stage III + IV squamous cell carcinoma of the lung (86.7%, 13/15) was significantly higher than its positive expression rate in stage I + II (50%, 10%). 2 0 ) (χ2 = 5.1, P <0.01); The 3-year survival rate of CD44V6-positive patients (30.4%, 7/23) was significantly lower than that of CD44V6-negative patients (66.7%). , 8/12) (χ2 =4.2, P<0.05). Conclusion CD44V6 may be related to the occurrence of squamous cell carcinoma of the lung; CD44V6 positive predicts that lymph node metastasis may occur in squamous cell carcinoma of the lung and play a role in the clinical staging of squamous cell carcinoma of the lung; CD44V6 positive can also be used as a reference index for evaluating the prognosis of squamous cell carcinoma of the lung.