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目的探讨冠心病患者血清胱抑素C(Cystatin C,Cys C)水平与急性冠脉综合征(ACS)的相关性及其临床意义。方法选择经冠状动脉造影检查的患者共132例,冠心病的诊断标准为冠状动脉造影证实至少有一支心外膜血管直径狭窄≥50%,并结合心电图、心肌酶学等检查结果分为对照组(30例)、稳定型心绞痛组(SAP,34例)、不稳定型心绞痛组(UA,35例)和急性心肌梗死组(AMI,33例)4组,采用免疫比浊法(IMT)检测血清Cys C的浓度。结果①各组间患者的年龄、性别、吸烟、高血压、糖尿病、高血脂等比较差异无统计学意义(P>0.05)。②各组间HsCRP比较,UA高于对照组和SAP,同时AMI明显高于对照组和SAP;各组间Cys C水平比较,差异有统计学意义(F=5.668,P值=0.002),其中UA高于对照组和SAP,AMI低于对照组和SAP。结论冠心病患者血清Cys C水平在ACS分层中有指导意义。
Objective To investigate the correlation between serum cystatin C (Cys C) and acute coronary syndrome (ACS) in patients with coronary heart disease and its clinical significance. Methods A total of 132 patients undergoing coronary angiography were selected. The diagnosis of coronary heart disease was confirmed by coronary angiography. At least one epicardial vessel diameter stenosis ≥50%. The results of electrocardiogram and myocardial enzymology were divided into control group (30 cases), stable angina pectoris group (SAP 34 cases), unstable angina pectoris group (35 cases) and acute myocardial infarction group (AMI 33 cases). Immunoturbidimetry (IMT) Serum Cys C concentration. Results ① There were no significant differences in age, sex, smoking, hypertension, diabetes, hyperlipidemia among all groups (P> 0.05). ②The HsCRP between groups was higher than that of control group and SAP group, while the AMI was significantly higher than that of control group and SAP group. There was significant difference in Cys C between groups (F = 5.668, P = 0.002) UA higher than the control group and SAP, AMI lower than the control group and SAP. Conclusion The level of serum Cys C in patients with coronary heart disease has guiding significance in the stratification of ACS.