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目的化学药物损伤皮肤后很容易留下瘢痕,自拟中药皮肤剥脱剂在避免化学药物损伤皮肤中的作用,为临床应用提供实验依据。方法将药物外用于豚鼠皮肤,观察不同时间、不同药物对豚鼠皮肤的损伤。结果3d后中药皮肤剥脱剂组对豚鼠皮肤损伤达(0.22±0.06)mm(棘细胞和真皮乳头层);贝克-戈登液组损伤达(0.53±0.03)mm(真皮网状层);杰森液组损伤达(0.10±0.02)mm(角质浅层);低浓度中药皮肤剥脱剂组损伤达(0.12±0.03)mm(角质层)。中药皮肤剥脱剂和贝克液组角质蛋白均出现凝固、坏死、真皮上中层胶原纤维发生重新排列,真皮网状层有中性粒细胞、巨噬细胞、淋巴细胞等炎性细胞浸润;基质对照组未见皮肤损伤。结论中药皮肤剥脱剂优于低浓度中药皮肤剥脱剂和化学剥脱剂,既能控制深度,避免太深引起瘢痕,又能加速表皮死亡细胞或受损细胞的脱换率。
The purpose of chemical drugs is very easy to leave scars after skin damage, self-made skin peeling Chinese medicine to avoid the role of chemical drugs in the skin damage, provide experimental basis for clinical application. Methods The drug was applied to the skin of guinea pigs to observe the damage to the guinea pig skin at different times and different drugs. Results After 3 days, skin lesions of guinea pig skin in the traditional Chinese medicine skin peeling agent group were (0.22±0.06) mm (barrocytes and dermis papillary layer); the damage in the Baker-Golden liquid group was (0.53±0.03) mm (dermis reticular layer); The damage of the Sen liquid group was (0.10 ± 0.02) mm (shallow keratin); the damage of the low-concentration Chinese medicine skin peeling group was (0.12 ± 0.03) mm (stratum corneum). Both the skin exfoliating agents of traditional Chinese medicine and the keratin proteins of Baker’s solution group were coagulated, necrotic, and the collagen fibers of the dermis were rearranged. The reticular layer of the dermis had infiltration of inflammatory cells such as neutrophils, macrophages and lymphocytes; the matrix control group. No skin damage was seen. Conclusion The skin peeling agent of traditional Chinese medicine is superior to the skin peeling agent and chemical peeling agent of low concentration of traditional Chinese medicine. It can not only control the depth, but also avoid the scar caused by too deep, but also accelerate the rate of degeneration of epidermal dead cells or damaged cells.