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干扰素是目前临床抗丙型肝炎病毒(HCV)治疗的主要药物,但长期使用可产生耐药。由于丙型肝炎病毒具有高度的种族特异性而缺乏经济的小动物模型,因此细胞模型的建立和应用已成为HCV感染防治研究的必要条件。本文重点介绍了HCV转染细胞模型的建立和耐干扰素HCV细胞模型的建立与应用方法。
Interferon is currently the main anti-hepatitis C virus (HCV) treatment of drugs, but long-term use can produce resistance. Because of the high racial specificity of hepatitis C virus and the lack of economical animal models, the establishment and application of cell models has become a prerequisite for the prevention and treatment of HCV infection. This article highlights the establishment of HCV transfected cell models and the establishment and application of interferon-resistant HCV cell models.