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目的探讨低频重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对急性脑梗死患者运动功能恢复的影响。方法选取44例急性脑梗死伴偏瘫的住院患者,随机分为低频刺激组和对照组。低频治疗组接受10次1 Hz rTMS治疗,患者在rTMS治疗后均进行运动功能训练。在治疗前、第10天、第40天对所有患者进行临床功能NIHSS评分、Barthel指数(BI)、Fugl-Meyer评分(FMA)。结果治疗前两组间NIHSS、BI、FMA比较差异不具有统计学意义(P>0.05)。经过治疗,两组的临床功能评分(NIHSS、BI、FMA)在治疗后第10天和40天时均较治疗前改善(P<0.01)。治疗后第10天和第40天时两组间的NIHSS、BI、FMA比较差异有统计学意义(P<0.01),其中,低频刺激组的运动功能恢复明显优于对照组。结论低频rTMS对急性期脑梗死后运动功能的恢复有促进作用,其效果在治疗结束后1个月仍然存在。
Objective To investigate the effect of low frequency repetitive transcranial magnetic stimulation (rTMS) on the recovery of motor function in patients with acute cerebral infarction. Methods Forty-four inpatients with acute cerebral infarction and hemiplegia were randomly divided into low-frequency stimulation group and control group. The low-frequency treatment group received 10 1 rTMS rTMS treatment, the patients after rTMS treatment of motor function training. All patients were evaluated NIHSS score, Barthel index (BI) and Fugl-Meyer score (FMA) before treatment, the 10th day and the 40th day. Results There was no significant difference in NIHSS, BI and FMA between the two groups before treatment (P> 0.05). After treatment, the scores of clinical function (NIHSS, BI, FMA) in both groups were improved (P <0.01) before treatment on the 10th day and 40th day after treatment. NIHSS, BI and FMA between the two groups had statistical significance at the 10th day and the 40th day after treatment (P <0.01). The motor function recovery of the low-frequency stimulation group was obviously better than that of the control group. Conclusions Low-frequency rTMS can promote the recovery of motor function after acute cerebral infarction, and the effect remains at 1 month after the end of treatment.