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目的分析c-Met基因在新疆哈萨克族(哈族)、汉族食管鳞癌患者中的表达及其与临床病理的相关性。方法收集2013年5月至2014年5月新疆医科大学附属肿瘤医院收治且手术切除的100例冰冻食管鳞状细胞癌组织以及配对对癌远端正常组织的标本,其中哈族50例,汉族50例。观察两组c-Met基因转录的m RNA的表达相关情况。结果在本次研究完成后我们发现,c-Met基因转录的m RNA在所有患者的食管鳞癌组织中共50例呈现阳性表达,其中汉族40例,哈族60例,配对癌远端的正常组织中6例呈现出阳性表达的情况,其中汉族2例,哈族4例,对于食管鳞癌组织及其配对的癌远端的正常组织相比,c-Met基因的表达呈现出明显增加的情况,并与肿瘤细胞的分化程度有较大的相关性。结论对于食管鳞癌患者而言,c-Met基因在部分的食管鳞癌的组织中会呈现出一种高表达的情况,同时与患者的性别、年龄以及肿瘤的发生部位并无显著的相关性,但与患者的肿瘤分化程度有着明显的相关性,同时c-Met的表达在哈族以及汉族患者的食管鳞癌中的表达差异无统计学意义。
Objective To analyze the expression of c-Met gene in Xinjiang Kazak (Kazakh) and Han esophageal squamous cell carcinoma and its correlation with clinical pathology. Methods 100 cases of frozen esophageal squamous cell carcinoma and matched pairs of distal normal tissues were collected from May 2013 to May 2014 in Cancer Hospital Affiliated to Xinjiang Medical University. Among them, 50 cases of Kazakh and 50 cases of Han example. The expression of m RNA transcribed by c-Met gene in two groups was observed. Results After the completion of this study, we found that m RNA transcribed by c-Met gene was positive in all patients with esophageal squamous cell carcinoma, of which 50 cases were Han, 40 cases were Kazakh, 60 cases matched with the normal tissue distal to the cancer 6 cases showed positive expression, including 2 cases of Han and 4 cases of Kazakh. The expression of c-Met gene was significantly increased in esophageal squamous cell carcinoma tissues and its matched normal tissues of cancer , And with the degree of differentiation of tumor cells have a greater correlation. Conclusion For esophageal squamous cell carcinoma patients, c-Met gene expression in some tissues of esophageal squamous cell carcinoma will show a high expression, at the same time with the patient’s gender, age and tumor location did not significantly correlated , But there was a significant correlation with the degree of tumor differentiation in patients. There was no significant difference in the expression of c-Met between esophageal squamous cell carcinoma and Han nationality.