为探讨缺氧新生鼠胃壁局部一氧化氮（ＮＯ）的改变，本文直接测定其胃壁一氧化氮合成酶（ＮＯＳ）活性，并采用ＮＡＤＰＨ二氢硫辛酰胺脱氢酶组织化学方法（ＮＤ法）观察胃壁各层ＮＯＳ分布的变化，结果发现：急性缺氧组与正常组相比，差异无显著性（Ｐ＞０．０５）。但在缺氧缺血性脑病（ＨＩＥ）组，胃壁ＮＯＳ活性明显增高（Ｐ＜０．０１），ＮＤ法定位显示ＮＯＳ阳性纤维及胞体明显增多表现在肌层，而粘膜及粘膜下层变化不明显。说明窒息时胃动力降低及胃粘膜病变与ＮＯ在胃壁内的改变有关。 In order to explore the changes of local nitric oxide (NO) in the hypoxic neonatal rat stomach, the activity of nitric oxide synthase (NOS) in the gastric wall was measured directly. The NADPH dihydrolipoamide dehydrogenase histochemical method (ND method) The changes of NOS distribution in the gastric wall were observed. The results showed that there was no significant difference between the acute hypoxia group and the normal group (P> 0.05). However, in HIE group, the activity of NOS in gastric wall was significantly increased (P <0.01). The localization of NOS-positive fibers and cell body in ND group showed that in the muscle layer, the changes of mucosa and submucosal layer were not obvious . Description of gastric motility asphyxia and gastric mucosal lesions and NO in the stomach wall changes.