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目的 研究血管内皮生长因子 (VEGF)在大肠癌中的表达及其与临床病理特征的关系。方法 采用免疫组织化学方法检测 80例大肠癌手术标本肿瘤组织内的血管内皮生长因子 (VEGF )和微血管计数 (MVD )。结果 VEGF表达阳性率为6 1.2 % ,VEGF表达阳性的肿瘤组织其MVD明显高于阴性者 (P <0 .0 5 )。VEGF表达与肿瘤的浸润性生长、浆膜浸润、淋巴结转移和肝转移有明显相关性 (P <0 .0 5 )。此外 ,VEGF表达阳性者的预后较阴性者差。多因素分析表明 ,VEGF是大肠癌的 1个独立预后因子。结论 VEGF是由肿瘤细胞所分泌的 ,它的表达与大肠癌的恶性进程和不良预后有关。
Objective To investigate the expression of vascular endothelial growth factor (VEGF) in colorectal carcinoma and its relationship with clinicopathological features. Methods Immunohistochemistry was used to detect the expression of vascular endothelial growth factor (VEGF) and microvessel count (MVD) in 80 cases of colorectal cancer specimens. Results The positive rate of VEGF expression was 62.2%. The MVD of VEGF-positive tumors was significantly higher than that of negative ones (P <0.05). There was a significant correlation between VEGF expression and invasive growth, serosal invasion, lymph node metastasis and liver metastasis (P <0.05). In addition, the prognosis of patients with positive VEGF expression is worse than that of negative ones. Multivariate analysis showed that VEGF is an independent prognostic factor for colorectal cancer. Conclusion VEGF is secreted by tumor cells and its expression is related to the malignant progression and poor prognosis of colorectal cancer.