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利用大鼠肾移植模型,观察雷公藤多甙(GTW)、雷公藤甲素及小剂量环孢霉素A(CsA)对大鼠肾移植急性排异反应的影响。结果证实,应用GTW或CsA后大鼠移植肾肾长明显减少,肾重明显减轻,肾小球基底膜增厚,肾小管空泡变性、坏死及间质水肿明显减轻;利用微机肾组织切片定量分析示移植术后第四、八天,肾小管面积、数量也明量增加,而间质面积明显减少。雷公藤甲素来证实有上述作用.另外,观察应用GTW治疗者,移植术后第九～第11天存活率明显增加.
The effects of GTW, triptolide and CsA on acute rejection of renal allograft in rats were observed using rat kidney transplantation model. The results confirmed that the application of GTW or CsA significantly reduced renal tubulointerstitial, renal significantly reduced, glomerular basement membrane thickening, tubular degeneration, necrosis and interstitial edema significantly reduced; the use of computerized kidney tissue sections quantitative Analysis showed that the fourth and eighth days after transplantation, tubule area, the amount of clear increase, while the interstitial area was significantly reduced. Triptolide to prove that the above effects.In addition, the observed application of GTW treatment, the ninth to the eleventh day after transplantation significantly increased survival.