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目的探究在妊娠期糖尿病孕妇体内转化生长因子β2(TGF-β2)、转化生长因子β受体Ⅱ(TGFβRⅡ)的表达情况并分析其临床意义。方法 78例妊娠期糖尿病孕妇作为观察组,78例正常孕妇作为对照组,对两组的TGF-β2、TGFβRⅡ的表达情况进行检测,并进行组间比较。结果观察组血清中的TGF-β2水平(384.72±35.94)pg/ml高于对照组的(161.63±21.90)pg/ml,差异具有统计学意义(P<0.05)。观察组TGF-β2、TGFβRⅡ的m RNA水平均高于对照组,差异均具有统计学意义(P<0.05)。观察组中TGF-β2、TGFβRⅡ的阳性率92.31%、87.18%均明显高于对照组的23.08%、20.51%,差异均具有统计学意义(P<0.05)。结论妊娠期糖尿病患者及正常孕妇的TGF-β2、TGFβRⅡ表达差异很大,TGF-β2、TGFβRⅡ联合检测对妊娠期糖尿病的诊断有很高的临床价值。
Objective To investigate the expression of transforming growth factor β2 (TGF-β2) and transforming growth factor β receptor Ⅱ (TGFβRII) in pregnant women with gestational diabetes mellitus and to analyze their clinical significance. Methods 78 pregnant women with gestational diabetes mellitus as observation group and 78 normal pregnant women as control group, the expression of TGF-β2 and TGFβRⅡ in both groups were detected and compared between groups. Results The serum level of TGF-β2 in the observation group (384.72 ± 35.94) pg / ml was higher than that in the control group (161.63 ± 21.90) pg / ml, with statistical significance (P <0.05). The m RNA levels of TGF-β2 and TGFβRⅡ in the observation group were significantly higher than those in the control group (P <0.05). The positive rates of TGF-β2 and TGFβRⅡ in the observation group were 92.31% and 87.18%, respectively, which were significantly higher than those in the control group (23.08% and 20.51%, both P <0.05). Conclusion The expression of TGF-β2 and TGFβRⅡ in patients with gestational diabetes mellitus and normal pregnant women are quite different. The combined detection of TGF-β2 and TGFβRⅡ has a high clinical value in the diagnosis of gestational diabetes mellitus.