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云南野生植物大暗消根中提得的白叶藤甙(Cryptolepisin)可使蛙心停止于收缩状态。兔静脉注射6毫克/公斤可使心动振幅增大,继而产生心率不整,最后停止于收缩期。按Langendorff法制备离体豚鼠心脏,1.5×10~(-5)溶液灌注时收缩振幅增大4—5倍,心率减慢,继而出现心收缩不规则,60分钟后停止于收缩期。3×10~(-5)溶液灌注时,作用更显著而迅速,20—30分钟后心脏停止于收缩状态。用乌拉坦麻醉的豚鼠作心电图观察时,本品能产生典型的洋地黄样心电图改变。按中国药典规定测定镐的最小致死量为2.914±0.037毫克/公斤。按户木田法预耠鸽50％致死量,24小时后测定其平均蓄积率为32.5％。
The Cryptolepisin extracted from the wild plants in Yunnan Province can cause the frog to stop in the contracted state. Intravenous injection of 6 mg / kg rabbit can increase the amplitude of the heartbeat, and then produce irregular heartbeat, and finally stopped at systole. According to the Langendorff method, the contraction amplitude of guinea pig hearts was increased 4-5 times with 1.5 × 10 ~ (-5) solution perfusion, the heart rate slowed down, then there was irregular heart contraction and stopped in systole after 60 minutes. 3 × 10 ~ (-5) solution perfusion, the role of more pronounced and rapid, 20-30 minutes after the heart stopped in contraction. Guinea pigs anesthetized with urethane for electrocardiographic observation, the goods can produce typical digitalis-like ECG changes. According to the provisions of the Chinese Pharmacopoeia Determination of the minimum lethal death was 2.914 ± 0.037 mg / kg. According to household Mu Tian law pre-pigeon 50% lethal dose, measured 24 hours after the average accumulation rate of 32.5%.