多聚乙酰(polyketide)类组成了一大系列由细菌(主要是放线菌)、真菌和植物产生的各种结构的复杂次级代谢物,其中大部分已证明是人用和兽用药品,在畜牧业则作为治疗用抗生素,化疗药物和生长刺激剂,还有一些较为重要的是真菌黄曲霉毒素,植物色素或香味物质。多聚乙酰的生物合成似乎类似于长链脂肪酸的生物合成。这种脂肪酸的生物合成是由以下反应重复循环进行的,即丙二酰基辅酶 A 衍生的二碳单位(乙酸残基),经缩 Polyketides make up a large series of complex secondary metabolites of various structures produced by bacteria, primarily actinomycetes, fungi and plants, most of which have been shown to be human and veterinary drugs, In the livestock industry as therapeutic antibiotics, chemotherapy drugs and growth stimulants, and some more important are fungal aflatoxins, plant pigments or fragrances. The biosynthesis of polymerases appears to be analogous to the biosynthesis of long chain fatty acids. The biosynthesis of this fatty acid is carried out by repeated cycles of the reaction of the two carbon units derived from malonyl-CoA (acetic acid residues)