目的：红霉素片溶出度中的定量测定。方法：以口占吨氢醇比色法用于红霉素片溶出度中的定量测定，并与药典上原有的方法进行了比较，讨论了口占吨氢醇试剂的浓度、反应温度、时间和冷却方法等因素对结果的影响。结果：定量测定回归方程中ｒ＝０．９９９７，线性范围为９０．９４９～１８１．８９８单位／ｍｌ，测定原料的回收率为９９．８６％，测定片剂的回收率１００．０５％。结论：新方法准确度和精密度均较好。 Objective: The quantitative determination of erythromycin tablets dissolution. Methods: The quantitative determination of erythromycin tablets by oral mass spectrometry was compared with the original method of Pharmacopoeia. The concentration, reaction temperature, time and cooling Method and other factors on the results. Results: The regression equation was r = 0.9997, the linear range was 90.949 ~ 181.898 units / ml, the recovery rate of raw materials was 99.86%, and the recovery rate of tablets was 100.05%. Conclusion: The new method is accurate and accurate.