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为研究抑制基因nm23表达产物二磷酸核甘激酸（NDPK）在人肺癌中的表达及其意义，应用LSAB免疫组化染色方法对121例人非小细胞癌进行了分析。结果显示：nm23在人肺癌中有较高的表达，阳性率为74．27％。在鳞癌的表达随着肿瘤的增大临床分期的进展而减弱，Ⅰ十Ⅱ高于Ⅲ十Ⅳ，中一高分化的高于低分化的。在腺癌的表达中一高分化的高于低分化的。鳞癌、腺癌及腺鳞癌3组中nm23原发灶的表达水平明显高于转移灶（淋巴结），癌旁正常细支气管粘膜和肺泡上皮组织明显高于癌组织。结果表明nm23基因在肺癌的发生、发展和转移中起一定的调节作用，并可能在肺癌中作为一种抑制基因而起作用。
In order to study the expression and significance of the inhibitory gene nm23 expression product nuclear phosphorylation (NDPK) in human lung cancer, 121 cases of human non-small cell carcinoma were analyzed by LSAB immunohistochemical staining. The results showed that nm23 was highly expressed in human lung cancer, with a positive rate of 74.27%. The expression of squamous cell carcinoma decreased with the progression of the clinical stage of the tumor, with I-II II being higher than III-IV IV, with medium-I highly differentiated compared to poorly-differentiated. A well-differentiated in adenocarcinoma expression is higher than poorly differentiated. The expression of nm23 primary tumor was significantly higher in squamous cell carcinoma, adenocarcinoma and adenosquamous carcinoma than in metastatic lesions (lymph nodes). The adjacent normal bronchiolar mucosa and alveolar epithelial tissues were significantly higher than those in cancerous tissues. The results show that nm23 gene plays a role in the regulation of the occurrence, development and metastasis of lung cancer, and may play a role as a suppressor gene in lung cancer.