头孢哌酮(Cefoperazone,CPZ,先锋必素)系第3代半合成头孢菌素。在我国是率先上市的第3代头孢菌素,也是目前临床常用的抗生素,毒副作用较小。但随着临床的广泛应用,也出现了一些严重不良反应,综述如下。1 过敏反应 常见的过敏反应是皮疹、药物热、发生率分别为1.1％,0.4％,一般较轻。CPZ也可引起过敏性休克和严重过敏性紫癜。1例慢支感染患者,首次静滴CPZ2.0,2min后出现过敏性休克,患者有链霉素、 Cefoperazone (CPZ, Pioneer B) is the third generation of semi-synthetic cephalosporins. In China is the first third-generation cephalosporin market, but also the current clinical antibiotics, less side effects. However, with the widespread use of clinical, there have been some serious adverse reactions, summarized as follows. Allergic reactions Common allergic reactions are rash, drug fever, the incidence was 1.1%, 0.4%, generally lighter. CPZ can also cause anaphylactic shock and severe allergic purpura. One case of chronic bronchitis infection, the first intravenous infusion of CPZ2.0, 2min after anaphylactic shock, patients with streptomycin,