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美国哈佛医学院和麻省中心医院的Paul S Russell在1981年10月报道第一例肾移植术中应用单克隆抗体的初步结果,并进行讨论。病例报告如下: 一个51岁的男性患者由于持续的蛋白尿和氮质血症而转入麻省中心医院。五年前为改善肢体血循曾急症、行右侧股动脉栓子取出术,当时发现有肾功能异常。术后恢复顺利。以后患者进入宾夕法尼亚医学院进一步诊治,发现有轻度高血压和双侧白内障。实验室检查:尿蛋白2.2g/天,BUN 40mg％,血肌酐2.8mg％,血胆固醇和甘油三酯235mg％。在一次痛风发作用别嘌呤醇治疗期间,血钙、磷、尿酸水平是正
Paul S Russell, Harvard Medical School and Massachusetts Central Hospital, USA, reported in October 1981 the first case of monoclonal antibody use in renal transplantation and discussed the results. The case report is as follows: A 51-year-old male patient was transferred to the Massachusetts Central Hospital as a result of persistent proteinuria and azotemia. Five years ago to improve limb blood circulation was acute, the right femoral artery embolization removed, was found to have renal dysfunction. Postoperative recovery was successful. After the patient into the Pennsylvania Medical School for further diagnosis and treatment, found to have mild hypertension and bilateral cataracts. Laboratory tests: urinary protein 2.2g / day, BUN 40mg%, serum creatinine 2.8mg%, blood cholesterol and triglyceride 235mg%. In a gout attack with allopurinol treatment, serum calcium, phosphorus, uric acid levels are positive