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目的:探讨更昔洛韦对小儿水痘的临床疗效及安全性。方法:66例水痘患儿随机分为2组,治疗组34例用更昔洛韦注射液5mg/(kg·d),对照组32例用利巴韦林注射液10mg/(kg·d),两组均每日一次静脉滴注,疗程5d,其他治疗方法相同。结果:治疗组热退及结痂时间较对照组缩短(P<0.05),且两组治疗前后周围血白细胞和中性粒细胞比较均无明显差异(P>0.05)。结论:更昔洛韦对小儿水痘有显著疗效,而且安全。
Objective: To investigate the clinical efficacy and safety of ganciclovir in children with chickenpox. Methods: 66 cases of chickenpox were randomly divided into two groups. 34 cases in the treatment group were treated with ganciclovir injection 5 mg / (kg · d), while in the control group, 32 cases were treated with ribavirin injection 10 mg / (kg · d) , Both groups once daily intravenous infusion, treatment 5d, the same as other treatments. Results: The thermal withdrawal and scabbing time in the treatment group were shorter than those in the control group (P <0.05). There was no significant difference in the peripheral blood leukocytes and neutrophils between the two groups before and after treatment (P> 0.05). Conclusion: Ganciclovir has a significant effect on pediatric chicken pox and is safe.