我国自制的长效口服避孕药复方18-甲基炔诺酮(乙炔雌二醇环戊醚3毫克,18-甲基炔诺酮12毫克,北京制药厂制)已广泛应用。每月服1片,有效率达98％,深受育龄妇女欢迎。但长期服用甾体类激素对妇女及其后代遗传学影响是一个非常重要的课题。本文对20例服用长效“复方18-甲”3年以上妇女和18例正常对照组妇女外周血淋巴细胞染色体畸 China’s long-acting oral contraceptive compound 18-norgestrel (ethinyl estradiol cyclopentyl ether 3 mg, 18-norgestrel 12 mg, Beijing Pharmaceutical Factory system) has been widely used. 1 serving a month, the effective rate of 98%, women of childbearing age are welcome. However, long-term use of steroid hormones on the genetic impact of women and their offspring is a very important issue. In this paper, 20 patients taking long-term “compound 18-A” more than 3 years of women and 18 normal control group of women with peripheral blood lymphocyte chromosome aberration