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环孢菌素 A(CsA)进一步代谢可产生二十余种代谢产物,本文报道其中八种主要代谢产物对猪管状细胞(LLC-PK_1)的作用。CsA 代谢产物的分离从服用 CsA 的肾移植患者尿中通过乙醚提取和高压液相色谱分离 CsA 代谢产物。代谢产物的结构和纯度通过 FAB/MS 和~1H、~(13)C NMR 方法测定。
Cyclosporine A (CsA) can further metabolize more than twenty metabolites. Here we report the effects of eight major metabolites on porcine tubular cells (LLC-PK 1). Separation of CsA Metabolites CsA metabolites were isolated from urine of kidney transplant recipients using CsA by ether extraction and high pressure liquid chromatography. The structure and purity of the metabolites were determined by FAB / MS and ~ 1H, ~ (13) C NMR methods.